ENSMUSG00000052139


Mus musculus

Features
Gene ID: ENSMUSG00000052139
  
Biological name :Babam2
  
Synonyms : Babam2 / BRISC and BRCA1-A complex member 2 / Q8K3W0
  
Possible biological names infered from orthology : Q9NXR7
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 31697684
Gene end: 32084962
  
Corresponding Affymetrix probe sets: 10520842 (MoGene1.0st)   1426312_at (Mouse Genome 430 2.0 Array)   1426313_at (Mouse Genome 430 2.0 Array)   1446758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128351
Ensembl peptide - ENSMUSP00000144497
Ensembl peptide - ENSMUSP00000144322
Ensembl peptide - ENSMUSP00000144205
Ensembl peptide - ENSMUSP00000143964
Ensembl peptide - ENSMUSP00000069133
Ensembl peptide - ENSMUSP00000071462
Ensembl peptide - ENSMUSP00000110152
Ensembl peptide - ENSMUSP00000110160
NCBI entrez gene - 107976     See in Manteia.
MGI - MGI:1333875
RefSeq - XM_011240687
RefSeq - NM_144541
RefSeq - NM_181279
RefSeq - NM_181280
RefSeq - NM_181281
RefSeq - NM_181282
RefSeq Peptide - NP_851799
RefSeq Peptide - NP_653124
RefSeq Peptide - NP_851796
RefSeq Peptide - NP_851797
RefSeq Peptide - NP_851798
swissprot - D3Z7P0
swissprot - Q8K3W0
swissprot - E9Q8Q1
swissprot - A0A0J9YV56
swissprot - E9Q0U3
Ensembl - ENSMUSG00000052139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 babam2ENSDARG00000038863Danio rerio
 BREENSGALG00000010039Gallus gallus
 BABAM2ENSG00000158019Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010358  BRCA1-A complex subunit BRE
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010212 response to ionizing radiation ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISO
 cellular_componentGO:0000152 nuclear ubiquitin ligase complex ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0070531 BRCA1-A complex IEA
 cellular_componentGO:0070552 BRISC complex IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IDA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding ISS


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Mpzl3tm1(KOMP)Mbp/Mpzl3tm1(KOMP)Mbp
Genetic Background: C57BL/6-Tyrc-Brd Mpzl3tm1(KOMP)Mbp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031820 Babam1 / Q3UI43 / BRISC and BRCA1-A complex member 1 / Q9NWV8* / AC010463.1*  / complex
 ENSMUSG00000032691 Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*  / complex
 ENSMUSG00000112039 Gm5136 / Q7M757 / predicted gene 5136 / BRCC3* / P46736* / BRCA1/BRCA2-containing complex subunit 3*  / complex






 

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