ENSG00000185515


Homo sapiens

Features
Gene ID: ENSG00000185515
  
Biological name :BRCC3
  
Synonyms : BRCA1/BRCA2-containing complex subunit 3 / BRCC3 / P46736
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q28
Gene start: 155071420
Gene end: 155123074
  
Corresponding Affymetrix probe sets: 216521_s_at (Human Genome U133 Plus 2.0 Array)   221196_x_at (Human Genome U133 Plus 2.0 Array)   229436_x_at (Human Genome U133 Plus 2.0 Array)   231913_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381998
Ensembl peptide - ENSP00000413170
Ensembl peptide - ENSP00000486287
Ensembl peptide - ENSP00000482836
Ensembl peptide - ENSP00000415152
Ensembl peptide - ENSP00000328641
Ensembl peptide - ENSP00000344103
Ensembl peptide - ENSP00000358471
Ensembl peptide - ENSP00000358474
Ensembl peptide - ENSP00000381988
NCBI entrez gene - 79184     See in Manteia.
OMIM - 300617
RefSeq - XM_017029838
RefSeq - NM_001018055
RefSeq - NM_001242640
RefSeq - NM_024332
RefSeq - XM_005274751
RefSeq Peptide - NP_001229569
RefSeq Peptide - NP_077308
RefSeq Peptide - NP_001018065
swissprot - A0A0A0MS96
swissprot - A0A087WZR3
swissprot - H7C413
swissprot - P46736
swissprot - H9KVA9
swissprot - X6RJS7
swissprot - A0A0D9SF50
Ensembl - ENSG00000185515
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brcc3ENSDARG00000098242Danio rerio
 BRCC3ENSGALG00000005383Gallus gallus
 Gm5136ENSMUSG00000112039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR033860  Brcc36 isopeptidase
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010165 response to X-ray IDA
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:0070537 histone H2A K63-linked deubiquitination IMP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0000152 nuclear ubiquitin ligase complex IDA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0070531 BRCA1-A complex IEA
 cellular_componentGO:0070552 BRISC complex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030234 enzyme regulator activity IDA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity TAS


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165660 Q15018 / ABRAXAS2 / abraxas 2, BRISC complex subunit  / complex
 ENSG00000162711 NLRP3 / Q96P20 / NLR family pyrin domain containing 3  / complex
 ENSG00000158019 BABAM2 / Q9NXR7 / BRISC and BRCA1 A complex member 2  / complex
 ENSG00000105393 BABAM1 / Q9NWV8 / BRISC and BRCA1 A complex member 1  / complex






 

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