ENSGALG00000005383


Gallus gallus

Features
Gene ID: ENSGALG00000005383
  
Biological name :BRCC3
  
Synonyms : BRCA1/BRCA2-containing complex subunit 3 / BRCC3
  
Possible biological names infered from orthology : Gm5136 / Lys-63-specific deubiquitinase BRCC36 / P46736 / P46737 / predicted gene 5136 / Q7M757
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 2200027
Gene end: 2204262
  
Corresponding Affymetrix probe sets: Gga.7155.1.S1_at (Chicken Array)   Gga.7155.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008634
NCBI entrez gene - 422201     See in Manteia.
RefSeq - XM_003641096
swissprot - E1C8A6
Ensembl - ENSGALG00000005383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brcc3ENSDARG00000098242Danio rerio
 BRCC3ENSG00000185515Homo sapiens
 Brcc3ENSMUSG00000031201Mus musculus
 Gm5136ENSMUSG00000112039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:0070537 histone H2A K63-linked deubiquitination IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000152 nuclear ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0070531 BRCA1-A complex IEA
 cellular_componentGO:0070552 BRISC complex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0030234 enzyme regulator activity IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010039 BRE / Q5ZML0 / BRISC and BRCA1-A complex member 2 / BABAM2* / Q8K3W0* / Q9NXR7*  / complex
 ENSGALG00000038054 FAM175B / BRISC complex subunit Abro1 / Q15018* / ABRAXAS2* / BRISC complex subunit* / abraxas 2, BRISC complex subunit*  / complex






 

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