ENSMUSG00000038393


Mus musculus

Features
Gene ID: ENSMUSG00000038393
  
Biological name :Txnip
  
Synonyms : Q8BG60 / thioredoxin interacting protein / Txnip
  
Possible biological names infered from orthology : Q9H3M7
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96557957
Gene end: 96561883
  
Corresponding Affymetrix probe sets: 10494428 (MoGene1.0st)   1415996_at (Mouse Genome 430 2.0 Array)   1415997_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041467
Ensembl peptide - ENSMUSP00000102710
NCBI entrez gene - 56338     See in Manteia.
MGI - MGI:1889549
RefSeq - NM_001009935
RefSeq - NM_023719
RefSeq Peptide - NP_001009935
RefSeq Peptide - NP_076208
swissprot - Q8BG60
Ensembl - ENSMUSG00000038393
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnipaENSDARG00000036107Danio rerio
 txnipbENSDARG00000070000Danio rerio
 TXNIPENSG00000265972Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arrdc3 / Q7TPQ9 / Arrestin domain-containing protein 3 / Q96B67* / arrestin domain containing 3*ENSMUSG0000007479441
Arrdc4 / A0A0B4J1F4 / Arrestin domain-containing protein 4 / Q8NCT1* / arrestin domain containing 4*ENSMUSG0000004265941
Arrdc2 / Q9D668 / Arrestin domain-containing protein 2 / Q8TBH0* / arrestin domain containing 2*ENSMUSG0000000291037
Arrdc1 / Q99KN1 / Arrestin domain-containing protein 1 / Q8N5I2* / arrestin domain containing 1*ENSMUSG0000002697221


Protein motifs (from Interpro)
Interpro ID Name
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0030216 keratinocyte differentiation ISO
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051782 negative regulation of cell division ISS
 biological_processGO:0071228 cellular response to tumor cell ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

Allelic Composition: Txniptm1Road/Txniptm1Road,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: HcB19/Dem-TxnipHyplip1

Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

Allelic Composition: Txniptm1Road/Txniptm1Road,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: B6.HcB19-TxnipHyplip1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

Allelic Composition: Txniptm1Road/Txniptm1Road,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: B6.HcB19-TxnipHyplip1

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: HcB19/Dem-TxnipHyplip1

Allelic Composition: TxnipHyplip1/Txnip+
Genetic Background: involves: CAST/Ei * HcB19/Dem

Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: involves: CAST/Ei * HcB19/Dem

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic Background: involves: 129S4/SvJae

 MP:0003926 impaired cellular glucose import "reduced ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Txniptm1Rlee/Txniptm1Rlee,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0005068 abnormal NK cell morphology/development "anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: HcB19/Dem-TxnipHyplip1

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: HcB19/Dem-TxnipHyplip1

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: TxnipHyplip1/TxnipHyplip1
Genetic Background: B6.HcB19-TxnipHyplip1

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

Allelic Composition: Txniptm1Road/Txniptm1Road,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

Allelic Composition: Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic Background: involves: 129S4/SvJae

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic Background: involves: 129S4/SvJae

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0006084 abnormal circulating phospholipid level "anomalous concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0012325 decreased circulating antithrombin level "lower than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation; low levels are associated with vein thrombosis and pulmonary embolism" [ISBN:0-683-40008-8, MPD:Molly]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0012356 increased prothrombin time "increased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0012359 increased partial thromboplastin time "increased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
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Allelic Composition: Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Txniptm1Rlee/Txniptm1Rlee,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Txniptm1.1Road/Txniptm1.1Road
Genetic Background: B6.Cg-Txniptm1.1Road

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / complex / reaction
 ENSMUSG00000032691 Nlrp3 / Q8R4B8 / NACHT, LRR and PYD domains-containing protein 3 / Q96P20* / NLR family pyrin domain containing 3*  / reaction / complex






 

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