ENSMUSG00000074794


Mus musculus

Features
Gene ID: ENSMUSG00000074794
  
Biological name :Arrdc3
  
Synonyms : Arrdc3 / Arrestin domain-containing protein 3 / Q7TPQ9
  
Possible biological names infered from orthology : arrestin domain containing 3 / Q96B67
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C2
Gene start: 80883384
Gene end: 80896042
  
Corresponding Affymetrix probe sets: 10406407 (MoGene1.0st)   1454617_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096957
Ensembl peptide - ENSMUSP00000125455
Ensembl peptide - ENSMUSP00000124418
NCBI entrez gene - 105171     See in Manteia.
MGI - MGI:2145242
RefSeq - NM_001042591
RefSeq - XM_006517017
RefSeq Peptide - NP_001036056
swissprot - E0CZE1
swissprot - Q7TPQ9
swissprot - E0CY84
Ensembl - ENSMUSG00000074794
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arrdc3aENSDARG00000052690Danio rerio
 ARRDC3ENSGALG00000025915Gallus gallus
 ARRDC3ENSG00000113369Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arrdc2 / Q9D668 / Arrestin domain-containing protein 2 / Q8TBH0* / arrestin domain containing 2*ENSMUSG0000000291051
Arrdc4 / A0A0B4J1F4 / Arrestin domain-containing protein 4 / Q8NCT1* / arrestin domain containing 4*ENSMUSG0000004265951
Txnip / Q8BG60 / thioredoxin interacting protein / Q9H3M7*ENSMUSG0000003839339
Arrdc1 / Q99KN1 / Arrestin domain-containing protein 1 / Q8N5I2* / arrestin domain containing 1*ENSMUSG0000002697221


Protein motifs (from Interpro)
Interpro ID Name
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0031651 negative regulation of heat generation IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0060613 fat pad development IMP
 biological_processGO:0071879 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IMP
 biological_processGO:0090327 negative regulation of locomotion involved in locomotory behavior IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0031699 beta-3 adrenergic receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3Gt(CSE513)Byg
Genetic Background: B6.129P2-Arrdc3Gt(CSE513)Byg

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3Gt(CSE513)Byg
Genetic Background: B6.129P2-Arrdc3Gt(CSE513)Byg

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3+
Genetic Background: B6.129P2-Arrdc3Gt(CSE513)Byg

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3Gt(CSE513)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3Gt(CSE513)Byg
Genetic Background: B6.129P2-Arrdc3Gt(CSE513)Byg

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3Gt(CSE513)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3Gt(CSE513)Byg
Genetic Background: B6.129P2-Arrdc3Gt(CSE513)Byg

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
Show

Allelic Composition: Arrdc3Gt(CSE151)Byg/Arrdc3Gt(CSE151)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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