ENSMUSG00000028367


Mus musculus

Features
Gene ID: ENSMUSG00000028367
  
Biological name :Txn1
  
Synonyms : P10639 / thioredoxin 1 / Txn1
  
Possible biological names infered from orthology : P10599 / thioredoxin / TXN
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 57943373
Gene end: 57956411
  
Corresponding Affymetrix probe sets: 10513195 (MoGene1.0st)   1416119_at (Mouse Genome 430 2.0 Array)   1456734_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030051
NCBI entrez gene - 22166     See in Manteia.
MGI - MGI:98874
RefSeq - NM_011660
RefSeq Peptide - NP_035790
swissprot - P10639
Ensembl - ENSMUSG00000028367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnENSDARG00000044125Danio rerio
 zgc:56493ENSDARG00000031435Danio rerio
 TXNENSGALG00000015704Gallus gallus
 TXNENSG00000136810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Txndc2 / thioredoxin domain containing 2 (spermatozoa) / Q86VQ3* / thioredoxin domain containing 2*ENSMUSG0000005061259
Q69AB2 / Txndc8 / thioredoxin domain containing 8 / Q6A555*ENSMUSG0000003870947
Txnl1 / Q8CDN6 / thioredoxin-like 1 / O43396*ENSMUSG0000002458340


Protein motifs (from Interpro)
Interpro ID Name
 IPR005746  Thioredoxin
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006662 glycerol ether metabolic process IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034599 cellular response to oxidative stress IBA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045454 cell redox homeostasis IDA
 biological_processGO:0046826 negative regulation of protein export from nucleus IDA
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IBA
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IDA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
 molecular_functionGO:0047134 protein-disulfide reductase activity IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005161 Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*  / reaction
 ENSMUSG00000020250 Q9JMH6 / Txnrd1 / thioredoxin reductase 1 / Q16881*  / reaction
 ENSMUSG00000020649 Rrm2 / P11157 / Ribonucleoside-diphosphate reductase subunit M2 / P31350* / AC007240.1* / ribonucleotide reductase regulatory subunit M2*  / reaction
 ENSMUSG00000023094 Msrb2 / Q78J03 / Methionine-R-sulfoxide reductase B2, mitochondrial / Q9Y3D2* / methionine sulfoxide reductase B2*  / reaction
 ENSMUSG00000024953 Prdx5 / P99029 / peroxiredoxin 5 / P30044*  / reaction
 ENSMUSG00000022292 Rrm2b / Q6PEE3 / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA. / Q7LG56* / ribonucleotide reductase regulatory TP53 inducible subunit M2B*  / reaction
 ENSMUSG00000028691 Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*  / reaction
 ENSMUSG00000038393 Txnip / Q8BG60 / thioredoxin interacting protein / Q9H3M7*  / complex / reaction
 ENSMUSG00000030978 Rrm1 / P07742 / Ribonucleoside-diphosphate reductase large subunit / P23921* / ribonucleotide reductase catalytic subunit M1*  / reaction
 ENSMUSG00000054733 Msra / Q9D6Y7 / Mitochondrial peptide methionine sulfoxide reductase / Q9UJ68* / methionine sulfoxide reductase A*  / reaction
 ENSMUSG00000071369 Map3k5 / O35099 / Mitogen-activated protein kinase kinase kinase 5 / Q99683*  / complex
 ENSMUSG00000051236 Msrb3 / methionine sulfoxide reductase B3 / Q8IXL7*  / reaction
 ENSMUSG00000075705 Msrb1 / Q9JLC3 / Mus musculus methionine sulfoxide reductase B1 (Msrb1), transcript variant 2, mRNA. / Q9NZV6* / methionine sulfoxide reductase B1*  / reaction






 

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