ENSMUSG00000051236


Mus musculus

Features
Gene ID: ENSMUSG00000051236
  
Biological name :Msrb3
  
Synonyms : methionine sulfoxide reductase B3 / Msrb3
  
Possible biological names infered from orthology : Q8IXL7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 120781096
Gene end: 120899101
  
Corresponding Affymetrix probe sets: 10372807 (MoGene1.0st)   1439151_at (Mouse Genome 430 2.0 Array)   1454997_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089781
Ensembl peptide - ENSMUSP00000115269
NCBI entrez gene - 320183     See in Manteia.
MGI - MGI:2443538
RefSeq - XM_006513763
RefSeq - XM_006513766
RefSeq - NM_177092
RefSeq - XM_006513764
RefSeq Peptide - NP_796066
swissprot - D3YUC9
swissprot - A0A0R4J139
Ensembl - ENSMUSG00000051236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msrb3ENSDARG00000045658Danio rerio
 MSRB3ENSGALG00000026661Gallus gallus
 MSRB3ENSG00000174099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Msrb2 / Q78J03 / Methionine-R-sulfoxide reductase B2, mitochondrial / Q9Y3D2* / methionine sulfoxide reductase B2*ENSMUSG0000002309438


Protein motifs (from Interpro)
Interpro ID Name
 IPR002579  Peptide methionine sulphoxide reductase MrsB
 IPR011057  Mss4-like superfamily
 IPR028427  Peptide methionine sulfoxide reductase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0030091 protein repair IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
 molecular_functionGO:0033743 peptide-methionine (R)-S-oxide reductase activity IEA


Pathways (from Reactome)
Pathway description
Protein repair


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0004530 absent outer hair cell stereocilia "complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction






 

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