ENSMUSG00000020250


Mus musculus

Features
Gene ID: ENSMUSG00000020250
  
Biological name :Txnrd1
  
Synonyms : Q9JMH6 / thioredoxin reductase 1 / Txnrd1
  
Possible biological names infered from orthology : Q16881
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 82833951
Gene end: 82897712
  
Corresponding Affymetrix probe sets: 10365260 (MoGene1.0st)   1421529_a_at (Mouse Genome 430 2.0 Array)   1424486_a_at (Mouse Genome 430 2.0 Array)   1424487_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151409
Ensembl peptide - ENSMUSP00000151825
Ensembl peptide - ENSMUSP00000152046
Ensembl peptide - ENSMUSP00000020484
Ensembl peptide - ENSMUSP00000151629
NCBI entrez gene - 50493     See in Manteia.
MGI - MGI:1354175
RefSeq - NM_001042513
RefSeq - NM_001042514
RefSeq - NM_001042523
RefSeq - NM_015762
RefSeq Peptide - NP_001035978
RefSeq Peptide - NP_001035979
RefSeq Peptide - NP_001035988
RefSeq Peptide - NP_056577
swissprot - Q9JMH6
swissprot - A0A1W2P6U1
Ensembl - ENSMUSG00000020250
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TXNRD1ENSGALG00000035345Gallus gallus
 Q16881ENSG00000198431Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Txnrd3 / thioredoxin reductase 3 / Q86VQ6*ENSMUSG0000000081172
Txnrd2 / thioredoxin reductase 2 / Q9NNW7*ENSMUSG0000007570455
Gsr / P47791 / Glutathione reductase, mitochondrial / P00390* / glutathione-disulfide reductase*ENSMUSG0000003158433


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006338  Thioredoxin/glutathione reductase selenoprotein
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000305 response to oxygen radical IBA
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity ISO
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
Metabolism of ingested MeSeO2H into MeSeH
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1smdg/Cacna1smdg
Genetic Background: involves: 129 * STOCK T/t4

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb7bhpls/Zbtb7bhpls
Genetic Background: involves: C57BL/6JAnu

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v/Cdh23v
Genetic Background: involves: fanciers stocks

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
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Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Hey2tm1Kkb/Hey2tm1Kkb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020250 Q9JMH6 / Txnrd1 / thioredoxin reductase 1 / Q16881*  / complex
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction






 

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