ENSMUSG00000031584


Mus musculus

Features
Gene ID: ENSMUSG00000031584
  
Biological name :Gsr
  
Synonyms : Glutathione reductase, mitochondrial / Gsr / P47791
  
Possible biological names infered from orthology : glutathione-disulfide reductase / P00390
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A3
Gene start: 33652523
Gene end: 33698163
  
Corresponding Affymetrix probe sets: 10571274 (MoGene1.0st)   1421816_at (Mouse Genome 430 2.0 Array)   1421817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033992
NCBI entrez gene - 14782     See in Manteia.
MGI - MGI:95804
RefSeq - NM_010344
RefSeq Peptide - NP_034474
swissprot - P47791
Ensembl - ENSMUSG00000031584
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsrENSDARG00000019236Danio rerio
 GSRENSGALG00000037781Gallus gallus
 GSRENSG00000104687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Txnrd2 / thioredoxin reductase 2 / Q9NNW7*ENSMUSG0000007570437
Txnrd3 / thioredoxin reductase 3 / Q86VQ6*ENSMUSG0000000081134
Q9JMH6 / Txnrd1 / thioredoxin reductase 1 / Q16881*ENSMUSG0000002025033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006322  Glutathione reductase, eukaryote/bacterial
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IC
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0004362 glutathione-disulfide reductase activity IDA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpm5tm1Sdmk/Trpm5tm1Sdmk
Genetic Background: involves: C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Kltm1Lex/Kltm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031584 Gsr / P47791 / Glutathione reductase, mitochondrial / P00390* / glutathione-disulfide reductase*  / complex






 

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