ENSG00000104687


Homo sapiens

Features
Gene ID: ENSG00000104687
  
Biological name :GSR
  
Synonyms : glutathione-disulfide reductase / GSR / P00390
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p12
Gene start: 30678061
Gene end: 30727999
  
Corresponding Affymetrix probe sets: 205770_at (Human Genome U133 Plus 2.0 Array)   225609_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494854
Ensembl peptide - ENSP00000444559
Ensembl peptide - ENSP00000445516
Ensembl peptide - ENSP00000221130
Ensembl peptide - ENSP00000431044
Ensembl peptide - ENSP00000438845
NCBI entrez gene - 2936     See in Manteia.
OMIM - 138300
RefSeq - NM_000637
RefSeq - NM_001195102
RefSeq - NM_001195103
RefSeq - NM_001195104
RefSeq Peptide - NP_001182032
RefSeq Peptide - NP_000628
RefSeq Peptide - NP_001182031
RefSeq Peptide - NP_001182033
swissprot - H0YC68
swissprot - P00390
swissprot - V9HW90
Ensembl - ENSG00000104687
  
Related genetic diseases (OMIM): 138300 - Hemolytic anemia due to glutathione reductase deficiency
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsrENSDARG00000019236Danio rerio
 GSRENSGALG00000037781Gallus gallus
 GsrENSMUSG00000031584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NNW7 / TXNRD2 / thioredoxin reductase 2ENSG0000018447036
Q16881 / TXNRD1 / thioredoxin reductase 1ENSG0000019843133
Q86VQ6 / TXNRD3 / thioredoxin reductase 3ENSG0000019776333


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006322  Glutathione reductase, eukaryote/bacterial
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004362 glutathione-disulfide reductase activity IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104687 GSR / P00390 / glutathione-disulfide reductase  / complex






 

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