ENSDARG00000019236


Danio rerio

Features
Gene ID: ENSDARG00000019236
  
Biological name :gsr
  
Synonyms : glutathione reductase / gsr
  
Possible biological names infered from orthology : glutathione-disulfide reductase / Glutathione reductase, mitochondrial / P00390 / P47791
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 38852969
Gene end: 38873145
  
Corresponding Affymetrix probe sets: Dr.17468.1.A1_at (Zebrafish Array)   NM_001020554_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113577
Ensembl peptide - ENSDARP00000153536
Ensembl peptide - ENSDARP00000142567
Ensembl peptide - ENSDARP00000142369
Ensembl peptide - ENSDARP00000124533
Ensembl peptide - ENSDARP00000047049
Ensembl peptide - ENSDARP00000108870
NCBI entrez gene - 553575     See in Manteia.
RefSeq - NM_001020554
RefSeq Peptide - NP_001018390
swissprot - A0A140LH37
swissprot - A0A140LGJ0
swissprot - F1QS99
swissprot - F8W316
swissprot - E9QJ27
swissprot - E7FGA5
ZFIN ID - ZDB-GENE-050522-116
Ensembl - ENSDARG00000019236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSRENSGALG00000037781Gallus gallus
 GSRENSG00000104687Homo sapiens
 GsrENSMUSG00000031584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
txnrd2.2 / thioredoxin reductase 2, tandem duplicate 2 / Q9NNW7* / TXNRD2* / thioredoxin reductase 2*ENSDARG0000007592335
txnrd3 / thioredoxin reductase 3 / Q86VQ6*ENSDARG0000010037432
txnrd2.1 / thioredoxin reductase 2, tandem duplicate 1 / Q9NNW7* / TXNRD2* / thioredoxin reductase 2*ENSDARG0000009447014


Protein motifs (from Interpro)
Interpro ID Name
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006322  Glutathione reductase, eukaryote/bacterial
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004362 glutathione-disulfide reductase activity IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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