ENSG00000197763


Homo sapiens

Features
Gene ID: ENSG00000197763
  
Biological name :TXNRD3
  
Synonyms : Q86VQ6 / thioredoxin reductase 3 / TXNRD3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.3
Gene start: 126607052
Gene end: 126655155
  
Corresponding Affymetrix probe sets: 221906_at (Human Genome U133 Plus 2.0 Array)   59631_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000492342
Ensembl peptide - ENSP00000429584
Ensembl peptide - ENSP00000430031
Ensembl peptide - ENSP00000492093
NCBI entrez gene - 114112     See in Manteia.
OMIM - 606235
RefSeq - NM_001173513
RefSeq - NM_052883
RefSeq Peptide - NP_001166984
RefSeq Peptide - NP_443115
swissprot - Q86VQ6
swissprot - A0A1W2PR67
swissprot - H0YBI6
swissprot - H0YBQ0
Ensembl - ENSG00000197763
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnrd3ENSDARG00000100374Danio rerio
 TXNRD3ENSGALG00000039363Gallus gallus
 Txnrd3ENSMUSG00000000811Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q16881 / TXNRD1 / thioredoxin reductase 1ENSG0000019843165
Q9NNW7 / TXNRD2 / thioredoxin reductase 2ENSG0000018447043
GSR / P00390 / glutathione-disulfide reductaseENSG0000010468727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR002109  Glutaredoxin
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006338  Thioredoxin/glutathione reductase selenoprotein
 IPR011899  Glutaredoxin, eukaryotic/virial
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000305 response to oxygen radical IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045454 cell redox homeostasis IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity NAS
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr