ENSG00000198431


Homo sapiens

Features
Gene ID: ENSG00000198431
  
Biological name :TXNRD1
  
Synonyms : Q16881 / thioredoxin reductase 1 / TXNRD1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q23.3
Gene start: 104215779
Gene end: 104350305
  
Corresponding Affymetrix probe sets: 1561080_at (Human Genome U133 Plus 2.0 Array)   201266_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433887
Ensembl peptide - ENSP00000431294
Ensembl peptide - ENSP00000431925
Ensembl peptide - ENSP00000432273
Ensembl peptide - ENSP00000432812
Ensembl peptide - ENSP00000433425
Ensembl peptide - ENSP00000433507
Ensembl peptide - ENSP00000433599
Ensembl peptide - ENSP00000433732
Ensembl peptide - ENSP00000433935
Ensembl peptide - ENSP00000436229
Ensembl peptide - ENSP00000435929
Ensembl peptide - ENSP00000435123
Ensembl peptide - ENSP00000434919
Ensembl peptide - ENSP00000434516
Ensembl peptide - ENSP00000347020
Ensembl peptide - ENSP00000373506
Ensembl peptide - ENSP00000380844
Ensembl peptide - ENSP00000412045
Ensembl peptide - ENSP00000421934
NCBI entrez gene - 7296     See in Manteia.
OMIM - 601112
RefSeq - NM_182743
RefSeq - NM_182742
RefSeq - NM_182729
RefSeq - NM_003330
RefSeq - NM_001261446
RefSeq - NM_001261445
RefSeq - NM_001093771
RefSeq Peptide - NP_001248374
RefSeq Peptide - NP_001087240
RefSeq Peptide - NP_001248375
RefSeq Peptide - NP_003321
RefSeq Peptide - NP_877393
RefSeq Peptide - NP_877419
RefSeq Peptide - NP_877420
swissprot - E9PJU2
swissprot - E9PIZ5
swissprot - E9PIR7
swissprot - E2QRB9
swissprot - A0A182DWI3
swissprot - A0A0B4J225
swissprot - A0A087WSY9
swissprot - Q16881
swissprot - A0A087WSW9
swissprot - E9PRI8
swissprot - E9PQI3
swissprot - E9PLT3
swissprot - E9PKI4
swissprot - E9PKD3
swissprot - F8W809
Ensembl - ENSG00000198431
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TXNRD1ENSGALG00000035345Gallus gallus
 Q9JMH6ENSMUSG00000020250Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86VQ6 / TXNRD3 / thioredoxin reductase 3ENSG0000019776364
Q9NNW7 / TXNRD2 / thioredoxin reductase 2ENSG0000018447043
GSR / P00390 / glutathione-disulfide reductaseENSG0000010468726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001100  Pyridine nucleotide-disulphide oxidoreductase, class I
 IPR002109  Glutaredoxin
 IPR003953  FAD-dependent oxidoreductase 2, FAD binding domain
 IPR004099  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
 IPR006338  Thioredoxin/glutathione reductase selenoprotein
 IPR012999  Pyridine nucleotide-disulphide oxidoreductase, class I, active site
 IPR016156  FAD/NAD-linked reductase, dimerisation domain superfamily
 IPR023753  FAD/NAD(P)-binding domain
 IPR036188  FAD/NAD(P)-binding domain superfamily
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000305 response to oxygen radical IBA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001887 selenium compound metabolic process TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0098625 methylselenol reductase activity TAS
 molecular_functionGO:0098626 methylseleninic acid reductase activity TAS


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
Metabolism of ingested MeSeO2H into MeSeH
Uptake and function of diphtheria toxin
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198431 Q16881 / TXNRD1 / thioredoxin reductase 1  / complex
 ENSG00000136810 TXN / P10599 / thioredoxin  / reaction






 

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