ENSG00000136810


Homo sapiens

Features
Gene ID: ENSG00000136810
  
Biological name :TXN
  
Synonyms : P10599 / thioredoxin / TXN
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q31.3
Gene start: 110243811
Gene end: 110256640
  
Corresponding Affymetrix probe sets: 208864_s_at (Human Genome U133 Plus 2.0 Array)   216609_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363639
Ensembl peptide - ENSP00000363641
NCBI entrez gene - 7295     See in Manteia.
OMIM - 187700
RefSeq - NM_001244938
RefSeq - NM_003329
RefSeq Peptide - NP_001231867
RefSeq Peptide - NP_003320
swissprot - P10599
swissprot - H9ZYJ2
Ensembl - ENSG00000136810
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txnENSDARG00000044125Danio rerio
 zgc:56493ENSDARG00000031435Danio rerio
 TXNENSGALG00000015704Gallus gallus
 Txn1ENSMUSG00000028367Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86VQ3 / TXNDC2 / thioredoxin domain containing 2ENSG0000016845460
Q6A555 / TXNDC8 / thioredoxin domain containing 8ENSG0000020419342
TXNL1 / O43396 / thioredoxin like 1ENSG0000009116441


Protein motifs (from Interpro)
Interpro ID Name
 IPR005746  Thioredoxin
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006662 glycerol ether metabolic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009314 response to radiation IDA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0030091 protein repair TAS
 biological_processGO:0032148 activation of protein kinase B activity IC
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IDA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0045454 cell redox homeostasis IBA
 biological_processGO:0046826 negative regulation of protein export from nucleus IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IC
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IBA
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IEA
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
 molecular_functionGO:0047134 protein-disulfide reductase activity IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Detoxification of Reactive Oxygen Species
Interconversion of nucleotide di- and triphosphates
TP53 Regulates Metabolic Genes
Protein repair
The NLRP3 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000048392 RRM2B / Q7LG56 / ribonucleotide reductase regulatory TP53 inducible subunit M2B  / reaction
 ENSG00000126432 PRDX5 / P30044 / peroxiredoxin 5  / reaction
 ENSG00000117450 PRDX1 / Q06830 / peroxiredoxin 1  / reaction
 ENSG00000167325 RRM1 / P23921 / ribonucleotide reductase catalytic subunit M1  / reaction
 ENSG00000174099 MSRB3 / Q8IXL7 / methionine sulfoxide reductase B3  / reaction
 ENSG00000167815 PRDX2 / P32119 / peroxiredoxin 2  / reaction
 ENSG00000171848 RRM2 / P31350 / ribonucleotide reductase regulatory subunit M2  / reaction
 ENSG00000175806 MSRA / Q9UJ68 / methionine sulfoxide reductase A  / reaction
 ENSG00000198736 MSRB1 / Q9NZV6 / methionine sulfoxide reductase B1  / reaction
 ENSG00000198431 Q16881 / TXNRD1 / thioredoxin reductase 1  / reaction
 ENSG00000197442 MAP3K5 / Q99683 / mitogen-activated protein kinase kinase kinase 5  / complex
 ENSG00000148450 MSRB2 / Q9Y3D2 / methionine sulfoxide reductase B2  / reaction
 ENSG00000265972 TXNIP / Q9H3M7 / thioredoxin interacting protein  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr