ENSG00000171848


Homo sapiens

Features
Gene ID: ENSG00000171848
  
Biological name :RRM2
  
Synonyms : P31350 / ribonucleotide reductase regulatory subunit M2 / RRM2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p25.1
Gene start: 10120698
Gene end: 10131419
  
Corresponding Affymetrix probe sets: 201890_at (Human Genome U133 Plus 2.0 Array)   209773_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484183
Ensembl peptide - ENSP00000493399
Ensembl peptide - ENSP00000302955
Ensembl peptide - ENSP00000353770
Ensembl peptide - ENSP00000419177
NCBI entrez gene - 6241     See in Manteia.
OMIM - 180390
RefSeq - NM_001034
RefSeq - NM_001165931
RefSeq Peptide - NP_001025
RefSeq Peptide - NP_001159403
swissprot - C9JXC1
swissprot - P31350
Ensembl - ENSG00000171848
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrm2ENSDARG00000020711Danio rerio
 rrm2ENSDARG00000078069Danio rerio
 ENSGALG00000016442Gallus gallus
 Rrm2ENSMUSG00000020649Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC007240.1ENSG0000028468176
RRM2B / Q7LG56 / ribonucleotide reductase regulatory TP53 inducible subunit M2BENSG0000004839261


Protein motifs (from Interpro)
Interpro ID Name
 IPR000358  Ribonucleotide reductase small subunit family
 IPR009078  Ferritin-like superfamily
 IPR030475  Ribonucleotide reductase small subunit, acitve site
 IPR033909  Ribonucleotide reductase small subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0009263 deoxyribonucleotide biosynthetic process IBA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005971 ribonucleoside-diphosphate reductase complex IBA
 molecular_functionGO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates
Activation of E2F1 target genes at G1/S
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167325 RRM1 / P23921 / ribonucleotide reductase catalytic subunit M1  / complex
 ENSG00000173221 GLRX / P35754 / glutaredoxin  / reaction
 ENSG00000171848 RRM2 / P31350 / ribonucleotide reductase regulatory subunit M2  / complex
 ENSG00000136810 TXN / P10599 / thioredoxin  / reaction






 

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