ENSG00000173221


Homo sapiens

Features
Gene ID: ENSG00000173221
  
Biological name :GLRX
  
Synonyms : GLRX / glutaredoxin / P35754
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q15
Gene start: 95751319
Gene end: 95823005
  
Corresponding Affymetrix probe sets: 206662_at (Human Genome U133 Plus 2.0 Array)   209276_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000237858
Ensembl peptide - ENSP00000422708
Ensembl peptide - ENSP00000424636
Ensembl peptide - ENSP00000427353
Ensembl peptide - ENSP00000369314
NCBI entrez gene - 2745     See in Manteia.
OMIM - 600443
RefSeq - NM_001118890
RefSeq - NM_001243658
RefSeq - NM_001243659
RefSeq - NM_002064
RefSeq Peptide - NP_001112362
RefSeq Peptide - NP_001230587
RefSeq Peptide - NP_001230588
RefSeq Peptide - NP_002055
swissprot - P35754
swissprot - A0A024RAM2
Ensembl - ENSG00000173221
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glrxENSDARG00000028106Danio rerio
 GLRXENSGALG00000027483Gallus gallus
 GlrxENSMUSG00000021591Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR011767  Glutaredoxin active site
 IPR011899  Glutaredoxin, eukaryotic/virial
 IPR014025  Glutaredoxin subgroup
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045838 positive regulation of membrane potential IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0080058 protein deglutathionylation TAS
 biological_processGO:2000651 positive regulation of sodium ion transmembrane transporter activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0015038 glutathione disulfide oxidoreductase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0097573 glutathione oxidoreductase activity TAS


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000048392 RRM2B / Q7LG56 / ribonucleotide reductase regulatory TP53 inducible subunit M2B  / reaction
 ENSG00000167325 RRM1 / P23921 / ribonucleotide reductase catalytic subunit M1  / reaction
 ENSG00000171848 RRM2 / P31350 / ribonucleotide reductase regulatory subunit M2  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr