ENSMUSG00000021591


Mus musculus

Features
Gene ID: ENSMUSG00000021591
  
Biological name :Glrx
  
Synonyms : Glrx / Glutaredoxin-1 / Q9QUH0
  
Possible biological names infered from orthology : glutaredoxin / P35754
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 75839868
Gene end: 75850154
  
Corresponding Affymetrix probe sets: 10406270 (MoGene1.0st)   1416592_at (Mouse Genome 430 2.0 Array)   1416593_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152829
Ensembl peptide - ENSMUSP00000022082
Ensembl peptide - ENSMUSP00000152802
NCBI entrez gene - 93692     See in Manteia.
MGI - MGI:2135625
RefSeq - NM_053108
RefSeq - XM_006517477
RefSeq Peptide - NP_444338
swissprot - A0A1Y7VM65
swissprot - Q3U6L3
swissprot - Q9QUH0
Ensembl - ENSMUSG00000021591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glrxENSDARG00000028106Danio rerio
 GLRXENSGALG00000027483Gallus gallus
 GLRXENSG00000173221Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002109  Glutaredoxin
 IPR011767  Glutaredoxin active site
 IPR011899  Glutaredoxin, eukaryotic/virial
 IPR014025  Glutaredoxin subgroup
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045838 positive regulation of membrane potential ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:2000651 positive regulation of sodium ion transmembrane transporter activity ISO
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0015038 glutathione disulfide oxidoreductase activity ISO
 molecular_functionGO:0019153 protein-disulfide reductase (glutathione) activity TAS
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mylktm1Mzhu/Mylktm1Mzhu,Taglntm1(cre/ERT2)Feil/?
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020649 Rrm2 / P11157 / Ribonucleoside-diphosphate reductase subunit M2 / P31350* / AC007240.1* / ribonucleotide reductase regulatory subunit M2*  / reaction
 ENSMUSG00000022292 Rrm2b / Q6PEE3 / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA. / Q7LG56* / ribonucleotide reductase regulatory TP53 inducible subunit M2B*  / reaction
 ENSMUSG00000030978 Rrm1 / P07742 / Ribonucleoside-diphosphate reductase large subunit / P23921* / ribonucleotide reductase catalytic subunit M1*  / reaction






 

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