ENSMUSG00000022292


Mus musculus

Features
Gene ID: ENSMUSG00000022292
  
Biological name :Rrm2b
  
Synonyms : Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA. / Q6PEE3 / Rrm2b
  
Possible biological names infered from orthology : Q7LG56 / ribonucleotide reductase regulatory TP53 inducible subunit M2B
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.1
Gene start: 37923952
Gene end: 37961318
  
Corresponding Affymetrix probe sets: 10428232 (MoGene1.0st)   1433773_at (Mouse Genome 430 2.0 Array)   1437221_at (Mouse Genome 430 2.0 Array)   1437222_x_at (Mouse Genome 430 2.0 Array)   1437476_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022901
Ensembl peptide - ENSMUSP00000123691
Ensembl peptide - ENSMUSP00000121188
Ensembl peptide - ENSMUSP00000121069
Ensembl peptide - ENSMUSP00000120215
Ensembl peptide - ENSMUSP00000119400
Ensembl peptide - ENSMUSP00000114343
NCBI entrez gene - 382985     See in Manteia.
MGI - MGI:2155865
RefSeq - XM_006520102
RefSeq - NM_001357022
RefSeq - NM_001357023
RefSeq - NM_199476
RefSeq - XM_006520101
RefSeq Peptide - NP_001343951
RefSeq Peptide - NP_001343952
RefSeq Peptide - NP_955770
swissprot - D3Z2A4
swissprot - D3Z0X2
swissprot - D3YXX2
swissprot - D6RFN4
swissprot - D3YVM0
swissprot - Q6PEE3
swissprot - D6RFP5
Ensembl - ENSMUSG00000022292
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrm2bENSDARG00000033367Danio rerio
 RRM2BENSGALG00000040921Gallus gallus
 RRM2BENSG00000048392Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rrm2 / P11157 / Ribonucleoside-diphosphate reductase subunit M2 / P31350* / AC007240.1* / ribonucleotide reductase regulatory subunit M2*ENSMUSG0000002064976


Protein motifs (from Interpro)
Interpro ID Name
 IPR000358  Ribonucleotide reductase small subunit family
 IPR009078  Ferritin-like superfamily
 IPR030475  Ribonucleotide reductase small subunit, acitve site
 IPR033909  Ribonucleotide reductase small subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006264 mitochondrial DNA replication IMP
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0009200 deoxyribonucleoside triphosphate metabolic process IMP
 biological_processGO:0009263 deoxyribonucleotide biosynthetic process IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005971 ribonucleoside-diphosphate reductase complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011359 decreased glomerular capillary number "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [MGI:csmith]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011454 abnormal glomerular endothelium fenestra morphology "any structural anomaly of the large plasma membrane-lined circular pores that perforate the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, are not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011498 abnormal glomerular capsule parietal layer morphology "any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011871 podocyte hypertrophy "increase in the bulk size of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, due to cell enlargement" [MGI:anna]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022292 Rrm2b / Q6PEE3 / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA. / Q7LG56* / ribonucleotide reductase regulatory TP53 inducible subunit M2B*  / complex
 ENSMUSG00000021591 Glrx / Q9QUH0 / Glutaredoxin-1 / P35754* / glutaredoxin*  / reaction
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction
 ENSMUSG00000030978 Rrm1 / P07742 / Ribonucleoside-diphosphate reductase large subunit / P23921* / ribonucleotide reductase catalytic subunit M1*  / complex






 

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