ENSMUSG00000030978


Mus musculus

Features
Gene ID: ENSMUSG00000030978
  
Biological name :Rrm1
  
Synonyms : P07742 / Ribonucleoside-diphosphate reductase large subunit / Rrm1
  
Possible biological names infered from orthology : P23921 / ribonucleotide reductase catalytic subunit M1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 102441695
Gene end: 102469771
  
Corresponding Affymetrix probe sets: 10555695 (MoGene1.0st)   1415878_at (Mouse Genome 430 2.0 Array)   1440073_at (Mouse Genome 430 2.0 Array)   1448127_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033283
Ensembl peptide - ENSMUSP00000147865
Ensembl peptide - ENSMUSP00000147692
NCBI entrez gene - 20133     See in Manteia.
MGI - MGI:98180
RefSeq - NM_009103
RefSeq Peptide - NP_033129
swissprot - A0A1B0GSB1
swissprot - A0A1B0GRW5
swissprot - P07742
Ensembl - ENSMUSG00000030978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrm1ENSDARG00000014017Danio rerio
 RRM1ENSGALG00000017350Gallus gallus
 RRM1ENSG00000167325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000788  Ribonucleotide reductase large subunit, C-terminal
 IPR005144  ATP-cone domain
 IPR008926  Ribonucleotide reductase R1 subunit, N-terminal
 IPR013346  Ribonucleotide reductase, class I , alpha subunit
 IPR013509  Ribonucleotide reductase large subunit, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006206 pyrimidine nucleobase metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009263 deoxyribonucleotide biosynthetic process IDA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0051259 protein complex oligomerization IPI
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005971 ribonucleoside-diphosphate reductase complex IMP
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017076 purine nucleotide binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

Allelic Composition: Rrm1tm1.1Ofc/Rrm1tm1.1Ofc,Tg(CAG-Rrm2)#Rsw/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Rrm1tm1.1Ofc/Rrm1tm1.1Ofc,Tg(CAG-Rrm2)#Rsw/Tg(CAG-Rrm2)#Rsw
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022292 Rrm2b / Q6PEE3 / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA. / Q7LG56* / ribonucleotide reductase regulatory TP53 inducible subunit M2B*  / complex
 ENSMUSG00000020649 Rrm2 / P11157 / Ribonucleoside-diphosphate reductase subunit M2 / P31350* / AC007240.1* / ribonucleotide reductase regulatory subunit M2*  / complex
 ENSMUSG00000030978 Rrm1 / P07742 / Ribonucleoside-diphosphate reductase large subunit / P23921* / ribonucleotide reductase catalytic subunit M1*  / complex
 ENSMUSG00000021591 Glrx / Q9QUH0 / Glutaredoxin-1 / P35754* / glutaredoxin*  / reaction
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction






 

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