ENSG00000167325


Homo sapiens

Features
Gene ID: ENSG00000167325
  
Biological name :RRM1
  
Synonyms : P23921 / ribonucleotide reductase catalytic subunit M1 / RRM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 4094707
Gene end: 4138876
  
Corresponding Affymetrix probe sets: 201476_s_at (Human Genome U133 Plus 2.0 Array)   201477_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435656
Ensembl peptide - ENSP00000300738
Ensembl peptide - ENSP00000436377
Ensembl peptide - ENSP00000431464
Ensembl peptide - ENSP00000434069
Ensembl peptide - ENSP00000432555
NCBI entrez gene - 6240     See in Manteia.
OMIM - 180410
RefSeq - XM_011520278
RefSeq - NM_001033
RefSeq - NM_001318064
RefSeq - NM_001318065
RefSeq Peptide - NP_001304994
RefSeq Peptide - NP_001317122
RefSeq Peptide - NP_001024
RefSeq Peptide - NP_001304993
swissprot - E9PL69
swissprot - H0YCY7
swissprot - E9PJ62
swissprot - P23921
swissprot - E9PRY9
swissprot - E9PP77
Ensembl - ENSG00000167325
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrm1ENSDARG00000014017Danio rerio
 RRM1ENSGALG00000017350Gallus gallus
 Rrm1ENSMUSG00000030978Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000788  Ribonucleotide reductase large subunit, C-terminal
 IPR005144  ATP-cone domain
 IPR008926  Ribonucleotide reductase R1 subunit, N-terminal
 IPR013346  Ribonucleotide reductase, class I , alpha subunit
 IPR013509  Ribonucleotide reductase large subunit, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006206 pyrimidine nucleobase metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009263 deoxyribonucleotide biosynthetic process IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0021846 cell proliferation in forebrain IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005971 ribonucleoside-diphosphate reductase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017076 purine nucleotide binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173221 GLRX / P35754 / glutaredoxin  / reaction
 ENSG00000048392 RRM2B / Q7LG56 / ribonucleotide reductase regulatory TP53 inducible subunit M2B  / complex
 ENSG00000171848 RRM2 / P31350 / ribonucleotide reductase regulatory subunit M2  / complex
 ENSG00000167325 RRM1 / P23921 / ribonucleotide reductase catalytic subunit M1  / complex
 ENSG00000136810 TXN / P10599 / thioredoxin  / reaction






 

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