ENSMUSG00000020649


Mus musculus

Features
Gene ID: ENSMUSG00000020649
  
Biological name :Rrm2
  
Synonyms : P11157 / Ribonucleoside-diphosphate reductase subunit M2 / Rrm2
  
Possible biological names infered from orthology : AC007240.1 / P31350 / ribonucleotide reductase regulatory subunit M2
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.3
Gene start: 24708241
Gene end: 24714146
  
Corresponding Affymetrix probe sets: 10394978 (MoGene1.0st)   1416120_at (Mouse Genome 430 2.0 Array)   1434437_x_at (Mouse Genome 430 2.0 Array)   1448226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119502
Ensembl peptide - ENSMUSP00000120893
Ensembl peptide - ENSMUSP00000020980
NCBI entrez gene - 20135     See in Manteia.
MGI - MGI:98181
RefSeq - NM_009104
RefSeq Peptide - NP_033130
swissprot - P11157
swissprot - D3Z0D8
swissprot - F6RUC3
Ensembl - ENSMUSG00000020649
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrm2ENSDARG00000020711Danio rerio
 rrm2ENSDARG00000078069Danio rerio
 ENSGALG00000016442Gallus gallus
 AC007240.1ENSG00000284681Homo sapiens
 RRM2ENSG00000171848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rrm2b / Q6PEE3 / Mus musculus ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), transcript variant 3, mRNA. / Q7LG56* / ribonucleotide reductase regulatory TP53 inducible subunit M2B*ENSMUSG0000002229268


Protein motifs (from Interpro)
Interpro ID Name
 IPR000358  Ribonucleotide reductase small subunit family
 IPR009078  Ferritin-like superfamily
 IPR030475  Ribonucleotide reductase small subunit, acitve site
 IPR033909  Ribonucleotide reductase small subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0009262 deoxyribonucleotide metabolic process IDA
 biological_processGO:0009263 deoxyribonucleotide biosynthetic process IEA
 biological_processGO:0051259 protein complex oligomerization IPI
 biological_processGO:0051290 protein heterotetramerization IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005971 ribonucleoside-diphosphate reductase complex IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008199 ferric iron binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021591 Glrx / Q9QUH0 / Glutaredoxin-1 / P35754* / glutaredoxin*  / reaction
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction
 ENSMUSG00000020649 Rrm2 / P11157 / Ribonucleoside-diphosphate reductase subunit M2 / P31350* / AC007240.1* / ribonucleotide reductase regulatory subunit M2*  / complex
 ENSMUSG00000030978 Rrm1 / P07742 / Ribonucleoside-diphosphate reductase large subunit / P23921* / ribonucleotide reductase catalytic subunit M1*  / complex






 

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