ENSG00000167815


Homo sapiens

Features
Gene ID: ENSG00000167815
  
Biological name :PRDX2
  
Synonyms : P32119 / peroxiredoxin 2 / PRDX2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.13
Gene start: 12796820
Gene end: 12801859
  
Corresponding Affymetrix probe sets: 201006_at (Human Genome U133 Plus 2.0 Array)   211658_at (Human Genome U133 Plus 2.0 Array)   215067_x_at (Human Genome U133 Plus 2.0 Array)   39729_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301522
Ensembl peptide - ENSP00000334063
NCBI entrez gene - 7001     See in Manteia.
OMIM - 600538
RefSeq - NM_005809
RefSeq Peptide - NP_005800
swissprot - A6NIW5
swissprot - P32119
swissprot - V9HW12
Ensembl - ENSG00000167815
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx2ENSDARG00000025350Danio rerio
 Gm5225ENSMUSG00000095266Mus musculus
 Prdx2ENSMUSG00000005161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRDX1 / Q06830 / peroxiredoxin 1ENSG0000011745078
PRDX4 / Q13162 / peroxiredoxin 4ENSG0000012313169
PRDX3 / P30048 / peroxiredoxin 3ENSG0000016567265


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress NAS
 biological_processGO:0019430 removal of superoxide radicals IDA
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0042744 hydrogen peroxide catabolic process TAS
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008379 thioredoxin peroxidase activity IDA
 molecular_functionGO:0016209 antioxidant activity NAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136810 TXN / P10599 / thioredoxin  / reaction
 ENSG00000167815 PRDX2 / P32119 / peroxiredoxin 2  / complex
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction






 

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