ENSG00000123131


Homo sapiens

Features
Gene ID: ENSG00000123131
  
Biological name :PRDX4
  
Synonyms : peroxiredoxin 4 / PRDX4 / Q13162
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.11
Gene start: 23664262
Gene end: 23686399
  
Corresponding Affymetrix probe sets: 201923_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368654
Ensembl peptide - ENSP00000413736
Ensembl peptide - ENSP00000368635
Ensembl peptide - ENSP00000368646
NCBI entrez gene - 10549     See in Manteia.
OMIM - 300927
RefSeq - XM_017029231
RefSeq - NM_006406
RefSeq - XM_005274438
RefSeq - XM_017029230
RefSeq Peptide - NP_006397
swissprot - Q13162
swissprot - V9HW63
swissprot - A6NJJ0
swissprot - H7C3T4
swissprot - A6NG45
Ensembl - ENSG00000123131
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx4ENSDARG00000069013Danio rerio
 PRDX4ENSGALG00000016357Gallus gallus
 Prdx4ENSMUSG00000025289Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRDX3 / P30048 / peroxiredoxin 3ENSG0000016567251
PRDX2 / P32119 / peroxiredoxin 2ENSG0000016781551
PRDX1 / Q06830 / peroxiredoxin 1ENSG0000011745050


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007252 I-kappaB phosphorylation TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0019471 4-hydroxyproline metabolic process IEA
 biological_processGO:0022417 protein maturation by protein folding IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2000255 negative regulation of male germ cell proliferation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008379 thioredoxin peroxidase activity TAS
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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