ENSMUSG00000025289


Mus musculus

Features
Gene ID: ENSMUSG00000025289
  
Biological name :Prdx4
  
Synonyms : O08807 / peroxiredoxin 4 / Prdx4
  
Possible biological names infered from orthology : Q13162
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F3
Gene start: 155323918
Gene end: 155340754
  
Corresponding Affymetrix probe sets: 10607475 (MoGene1.0st)   1416166_a_at (Mouse Genome 430 2.0 Array)   1416167_at (Mouse Genome 430 2.0 Array)   1431269_at (Mouse Genome 430 2.0 Array)   1435731_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026328
Ensembl peptide - ENSMUSP00000122997
NCBI entrez gene - 53381     See in Manteia.
MGI - MGI:1859815
RefSeq - XM_011247844
RefSeq - NM_001313711
RefSeq - NM_016764
RefSeq Peptide - NP_001300640
RefSeq Peptide - NP_058044
swissprot - O08807
swissprot - B1AZS9
Ensembl - ENSMUSG00000025289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx4ENSDARG00000069013Danio rerio
 PRDX4ENSGALG00000016357Gallus gallus
 PRDX4ENSG00000123131Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*ENSMUSG0000000516149
Prdx3 / P20108 / Thioredoxin-dependent peroxide reductase, mitochondrial / P30048* / peroxiredoxin 3*ENSMUSG0000002499748
Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*ENSMUSG0000002869148
Gm5225 / PRDX2* / P32119* / peroxiredoxin 2*ENSMUSG0000009526621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0019471 4-hydroxyproline metabolic process IGI
 biological_processGO:0022417 protein maturation by protein folding IGI
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2000255 negative regulation of male germ cell proliferation IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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