ENSMUSG00000024997


Mus musculus

Features
Gene ID: ENSMUSG00000024997
  
Biological name :Prdx3
  
Synonyms : P20108 / Prdx3 / Thioredoxin-dependent peroxide reductase, mitochondrial
  
Possible biological names infered from orthology : P30048 / peroxiredoxin 3
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: D3
Gene start: 60864051
Gene end: 60874556
  
Corresponding Affymetrix probe sets: 10468869 (MoGene1.0st)   1416292_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025961
NCBI entrez gene - 11757     See in Manteia.
MGI - MGI:88034
RefSeq - NM_007452
RefSeq Peptide - NP_031478
swissprot - P20108
Ensembl - ENSMUSG00000024997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx3ENSDARG00000032102Danio rerio
 PRDX3ENSGALG00000009369Gallus gallus
 PRDX3ENSG00000165672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdx4 / O08807 / peroxiredoxin 4 / Q13162*ENSMUSG0000002528951
Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*ENSMUSG0000000516149
Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*ENSMUSG0000002869147
Gm5225 / PRDX2* / P32119* / peroxiredoxin 2*ENSMUSG0000009526622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0018171 peptidyl-cysteine oxidation IEA
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008385 IkappaB kinase complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008379 thioredoxin peroxidase activity IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0008902 abnormal renal fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024997 Prdx3 / P20108 / Thioredoxin-dependent peroxide reductase, mitochondrial / P30048* / peroxiredoxin 3*  / complex
 ENSMUSG00000005354 Txn2 / P97493 / thioredoxin 2 / Q99757*  / reaction






 

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