ENSMUSG00000005354


Mus musculus

Features
Gene ID: ENSMUSG00000005354
  
Biological name :Txn2
  
Synonyms : P97493 / thioredoxin 2 / Txn2
  
Possible biological names infered from orthology : Q99757
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 77915047
Gene end: 77929006
  
Corresponding Affymetrix probe sets: 10430247 (MoGene1.0st)   1421557_x_at (Mouse Genome 430 2.0 Array)   1452782_a_at (Mouse Genome 430 2.0 Array)   1455640_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133605
Ensembl peptide - ENSMUSP00000134682
Ensembl peptide - ENSMUSP00000005487
Ensembl peptide - ENSMUSP00000098055
Ensembl peptide - ENSMUSP00000105369
Ensembl peptide - ENSMUSP00000105370
NCBI entrez gene - 56551     See in Manteia.
MGI - MGI:1929468
RefSeq - NM_019913
RefSeq Peptide - NP_064297
swissprot - P97493
swissprot - A2A439
swissprot - Q3TUS3
swissprot - G3UX99
swissprot - G3UZY2
Ensembl - ENSMUSG00000005354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txn2ENSDARG00000034777Danio rerio
 TXN2ENSGALG00000012532Gallus gallus
 TXN2ENSG00000100348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005746  Thioredoxin
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006662 glycerol ether metabolic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0008113 peptide-methionine (S)-S-oxide reductase activity IEA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0033743 peptide-methionine (R)-S-oxide reductase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of cysteine and homocysteine
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Zeb1Tw/Zeb1Tw
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024997 Prdx3 / P20108 / Thioredoxin-dependent peroxide reductase, mitochondrial / P30048* / peroxiredoxin 3*  / reaction
 ENSMUSG00000024953 Prdx5 / P99029 / peroxiredoxin 5 / P30044*  / reaction
 ENSMUSG00000071711 Mpst / mercaptopyruvate sulfurtransferase / P25325*  / complex / reaction






 

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