ENSMUSG00000024953


Mus musculus

Features
Gene ID: ENSMUSG00000024953
  
Biological name :Prdx5
  
Synonyms : P99029 / peroxiredoxin 5 / Prdx5
  
Possible biological names infered from orthology : P30044
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6906697
Gene end: 6910106
  
Corresponding Affymetrix probe sets: 10465474 (MoGene1.0st)   1416381_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025904
Ensembl peptide - ENSMUSP00000134521
Ensembl peptide - ENSMUSP00000135084
NCBI entrez gene - 54683     See in Manteia.
MGI - MGI:1859821
RefSeq - NM_012021
RefSeq - NM_001358444
RefSeq Peptide - NP_001345373
RefSeq Peptide - NP_036151
swissprot - P99029
swissprot - H3BJQ7
swissprot - G3UZJ4
Ensembl - ENSMUSG00000024953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx5ENSDARG00000055064Danio rerio
 PRDX5ENSG00000126432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013740  Redoxin
 IPR013766  Thioredoxin domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0016480 negative regulation of transcription by RNA polymerase III IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process ISO
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0051354 negative regulation of oxidoreductase activity ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060785 regulation of apoptosis involved in tissue homeostasis ISO
 biological_processGO:0070995 NADPH oxidation ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2001057 reactive nitrogen species metabolic process ISO
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005782 peroxisomal matrix ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001016 RNA polymerase III regulatory region DNA binding IEA
 molecular_functionGO:0004601 peroxidase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008379 thioredoxin peroxidase activity ISO
 molecular_functionGO:0016209 antioxidant activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity ISO
 molecular_functionGO:0072541 peroxynitrite reductase activity ISO


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction
 ENSMUSG00000005354 Txn2 / P97493 / thioredoxin 2 / Q99757*  / reaction






 

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