ENSG00000126432


Homo sapiens

Features
Gene ID: ENSG00000126432
  
Biological name :PRDX5
  
Synonyms : P30044 / peroxiredoxin 5 / PRDX5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64318088
Gene end: 64321811
  
Corresponding Affymetrix probe sets: 1560587_s_at (Human Genome U133 Plus 2.0 Array)   222994_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265462
Ensembl peptide - ENSP00000335334
Ensembl peptide - ENSP00000335363
NCBI entrez gene - 25824     See in Manteia.
OMIM - 606583
RefSeq - XM_005273882
RefSeq - NM_012094
RefSeq - NM_181651
RefSeq - NM_181652
RefSeq Peptide - NP_857634
RefSeq Peptide - NP_857635
RefSeq Peptide - NP_036226
swissprot - P30044
Ensembl - ENSG00000126432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx5ENSDARG00000055064Danio rerio
 Prdx5ENSMUSG00000024953Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013740  Redoxin
 IPR013766  Thioredoxin domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0016480 negative regulation of transcription by RNA polymerase III IDA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001016 RNA polymerase III regulatory region DNA binding IDA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0008379 thioredoxin peroxidase activity EXP
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0046983 protein dimerization activity IDA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136810 TXN / P10599 / thioredoxin  / reaction
 ENSG00000100348 TXN2 / Q99757 / thioredoxin 2  / reaction






 

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