ENSMUSG00000005161


Mus musculus

Features
Gene ID: ENSMUSG00000005161
  
Biological name :Prdx2
  
Synonyms : Peroxiredoxin-2 / Prdx2 / Q61171
  
Possible biological names infered from orthology : P32119
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 84969587
Gene end: 84974834
  
Corresponding Affymetrix probe sets: 10356999 (MoGene1.0st)   10573483 (MoGene1.0st)   1418506_a_at (Mouse Genome 430 2.0 Array)   1430979_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122694
Ensembl peptide - ENSMUSP00000126451
Ensembl peptide - ENSMUSP00000005292
Ensembl peptide - ENSMUSP00000105355
Ensembl peptide - ENSMUSP00000105356
NCBI entrez gene - 21672     See in Manteia.
MGI - MGI:109486
RefSeq - NM_001317385
RefSeq - NM_011563
RefSeq Peptide - NP_001304314
RefSeq Peptide - NP_035693
swissprot - D3Z4A4
swissprot - Q61171
Ensembl - ENSMUSG00000005161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx2ENSDARG00000025350Danio rerio
 PRDX2ENSG00000167815Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*ENSMUSG0000002869175
Prdx4 / O08807 / peroxiredoxin 4 / Q13162*ENSMUSG0000002528968
Prdx3 / P20108 / Thioredoxin-dependent peroxide reductase, mitochondrial / P30048* / peroxiredoxin 3*ENSMUSG0000002499764
Gm5225 / PRDX2* / P32119* / peroxiredoxin 2*ENSMUSG0000009526642


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0002536 respiratory burst involved in inflammatory response IMP
 biological_processGO:0006979 response to oxidative stress TAS
 biological_processGO:0010310 regulation of hydrogen peroxide metabolic process IMP
 biological_processGO:0019430 removal of superoxide radicals IMP
 biological_processGO:0030194 positive regulation of blood coagulation IMP
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042743 hydrogen peroxide metabolic process IMP
 biological_processGO:0042744 hydrogen peroxide catabolic process IMP
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0045581 negative regulation of T cell differentiation IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0004601 peroxidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008379 thioredoxin peroxidase activity TAS
 molecular_functionGO:0008430 selenium binding TAS
 molecular_functionGO:0016209 antioxidant activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0011171 increased number of Heinz bodies "presence of intracellular inclusions usually attached to the red blood cell membrane, resulting from oxidative injury to and precipitation of hemoglobin in red blood cells" [http://www.dorlands.com/]
Show

Allelic Composition: Portm1Ding/Portm1Ding,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028367 Txn1 / P10639 / thioredoxin 1 / TXN* / P10599* / thioredoxin*  / reaction
 ENSMUSG00000005161 Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*  / complex
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / reaction
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / reaction






 

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