ENSMUSG00000048895


Mus musculus

Features
Gene ID: ENSMUSG00000048895
  
Biological name :Cdk5r1
  
Synonyms : Cdk5r1 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / P61809
  
Possible biological names infered from orthology : cyclin dependent kinase 5 regulatory subunit 1 / Q15078
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 80477023
Gene end: 80481184
  
Corresponding Affymetrix probe sets: 10379482 (MoGene1.0st)   1421123_at (Mouse Genome 430 2.0 Array)   1421124_at (Mouse Genome 430 2.0 Array)   1433450_at (Mouse Genome 430 2.0 Array)   1433451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120964
Ensembl peptide - ENSMUSP00000099514
NCBI entrez gene - 12569     See in Manteia.
MGI - MGI:101764
RefSeq - NM_009871
RefSeq Peptide - NP_034001
swissprot - B1AQH0
swissprot - P61809
swissprot - Q542T9
Ensembl - ENSMUSG00000048895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk5r1aENSDARG00000037916Danio rerio
 cdk5r1bENSDARG00000045087Danio rerio
 CDK5R1ENSGALG00000041907Gallus gallus
 CDK5R1ENSG00000176749Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk5r2 / O35926 / Cyclin-dependent kinase 5 activator 2 / Q13319* / cyclin dependent kinase 5 regulatory subunit 2*ENSMUSG0000009007154


Protein motifs (from Interpro)
Interpro ID Name
 IPR004944  Cyclin-dependent kinase 5 activator
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0007158 neuron cell-cell adhesion IMP
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021722 superior olivary nucleus maturation IGI
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021819 layer formation in cerebral cortex IGI
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030517 negative regulation of axon extension IGI
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0042501 serine phosphorylation of STAT protein IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016533 protein kinase 5 complex IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043292 contractile fiber IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016534 cyclin-dependent protein kinase 5 activator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IPI
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0051015 actin filament binding IPI


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000884 delaminated Purkinje cell layer "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: a8R/a8R
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Cdk5r1tm2Ohsh/Cdk5r1tm2Ohsh,Tg(Pcp2-cre)1Amc/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: a8R/a8R
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk5r1tm2Ohsh/Cdk5r1tm2Ohsh,Tg(Pcp2-cre)1Amc/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: a8R/a8R
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5r1tm2Ohsh/Cdk5r1tm2Ohsh,Tg(Pcp2-cre)1Amc/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdk5r1tm2Ohsh/Cdk5r1tm2Ohsh,Tg(Pcp2-cre)1Amc/0
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: a8R/a8R
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0002883 chromatolysis "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0003927 enhanced cellular glucose import "improved ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008440 abnormal subplate morphology "any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0009718 absent Purkinje cell layer "there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1+,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: a8R/a8R
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: a8R/a8R
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011624 abnormal sensitization to xenobiotic "anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a xenobiotic" [MGI:csmith]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae

 MP:0012318 slow extinction of fear memory "impaired ability or inability to extinguish aversive memories associated with a traumatic incident" [http://www.mpipsykl.mpg.de/en/research/themes/depression/wotjak_02/]
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000024942 Capn1 / O35350 / Calpain-1 catalytic subunit / P07384* / calpain 1*  / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex
 ENSMUSG00000026509 Capn2 / O08529 / Calpain-2 catalytic subunit / P17655* / calpain 2*  / reaction
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSMUSG00000028691 Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*  / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / reaction
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex
 ENSMUSG00000005161 Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*  / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000078144 Capns2 / Q9D7J7 / Calpain small subunit 2 / Q96L46*  / reaction






 

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