ENSMUSG00000026509


Mus musculus

Features
Gene ID: ENSMUSG00000026509
  
Biological name :Capn2
  
Synonyms : Calpain-2 catalytic subunit / Capn2 / O08529
  
Possible biological names infered from orthology : calpain 2 / P17655
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H5
Gene start: 182467260
Gene end: 182517608
  
Corresponding Affymetrix probe sets: 10360806 (MoGene1.0st)   1416257_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068895
NCBI entrez gene - 12334     See in Manteia.
MGI - MGI:88264
RefSeq - NM_009794
RefSeq Peptide - NP_033924
swissprot - O08529
Ensembl - ENSMUSG00000026509
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn2aENSDARG00000091699Danio rerio
 capn2bENSDARG00000055592Danio rerio
 zgc:92480ENSDARG00000034211Danio rerio
 CAPN2ENSGALG00000009360Gallus gallus
 CAPN2ENSG00000162909Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Capn1 / O35350 / Calpain-1 catalytic subunit / P07384* / calpain 1*ENSMUSG0000002494261
Capn8 / Q91VA3 / Calpain-8 / A6NHC0*ENSMUSG0000003859961
Capn3 / Q64691 / Calpain-3 / P20807*ENSMUSG0000007911051
Capn11 / Q6J756 / Calpain-11 / Q9UMQ6*ENSMUSG0000005862651
Capn9 / Q9D805 / Calpain-9 / O14815*ENSMUSG0000003198149
Capn12 / calpain 12 / Q6ZSI9*ENSMUSG0000005408342
Capn13 / Q3UW68 / Calpain-13 / Q6MZZ7*ENSMUSG0000004370531
Capn5 / O08688 / Calpain-5 / O15484*ENSMUSG0000003554730
Capn6 / O35646 / Calpain-6 / Q9Y6Q1*ENSMUSG0000006727628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR029539  Calpain-2
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0007520 myoblast fusion IMP
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Fas+,Tg(TcraTcrb)1100Mjb/?
Genetic Background: involves: C57BL/6 * MRL/Mp

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001794 Capns1 / calpain small subunit 1 / P04632*  / complex
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / reaction
 ENSMUSG00000078144 Capns2 / Q9D7J7 / Calpain small subunit 2 / Q96L46*  / complex






 

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