ENSMUSG00000038599


Mus musculus

Features
Gene ID: ENSMUSG00000038599
  
Biological name :Capn8
  
Synonyms : Calpain-8 / Capn8 / Q91VA3
  
Possible biological names infered from orthology : A6NHC0
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H5
Gene start: 182565007
Gene end: 182632352
  
Corresponding Affymetrix probe sets: 10352416 (MoGene1.0st)   1421634_at (Mouse Genome 430 2.0 Array)   1425916_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141275
Ensembl peptide - ENSMUSP00000047164
Ensembl peptide - ENSMUSP00000129549
NCBI entrez gene - 170725     See in Manteia.
MGI - MGI:2181366
RefSeq - XM_017319052
RefSeq - NM_001145806
RefSeq - NM_130890
RefSeq - XM_006496686
RefSeq - XM_006496688
RefSeq Peptide - NP_570960
RefSeq Peptide - NP_001139278
swissprot - A0A0R4J0K6
swissprot - Q91VA3
swissprot - A0A0A6YVU9
Ensembl - ENSMUSG00000038599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn8ENSDARG00000055715Danio rerio
 CAPN8ENSGALG00000009382Gallus gallus
 CAPN8ENSG00000203697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Capn2 / O08529 / Calpain-2 catalytic subunit / P17655* / calpain 2*ENSMUSG0000002650960
Capn1 / O35350 / Calpain-1 catalytic subunit / P07384* / calpain 1*ENSMUSG0000002494256
Capn3 / Q64691 / Calpain-3 / P20807*ENSMUSG0000007911049
Capn9 / Q9D805 / Calpain-9 / O14815*ENSMUSG0000003198149
Capn11 / Q6J756 / Calpain-11 / Q9UMQ6*ENSMUSG0000005862648
Capn12 / calpain 12 / Q6ZSI9*ENSMUSG0000005408342
Capn5 / O08688 / Calpain-5 / O15484*ENSMUSG0000003554731
Capn13 / Q3UW68 / Calpain-13 / Q6MZZ7*ENSMUSG0000004370531
Capn6 / O35646 / Calpain-6 / Q9Y6Q1*ENSMUSG0000006727627


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR011992  EF-hand domain pair
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR029543  Calpain-8
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0007586 digestion IEA
 biological_processGO:0051260 protein homooligomerization IPI
 biological_processGO:1990092 calcium-dependent self proteolysis IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IMP
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp5se/Bmp5se-1FrThc
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Capn8tm2.1Hiso/Capn8tm2.1Hiso
Genetic Background: C57BL/6-Capn8tm2.1Hiso

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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