ENSMUSG00000024942


Mus musculus

Features
Gene ID: ENSMUSG00000024942
  
Biological name :Capn1
  
Synonyms : Calpain-1 catalytic subunit / Capn1 / O35350
  
Possible biological names infered from orthology : calpain 1 / P07384
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5988546
Gene end: 6015825
  
Corresponding Affymetrix probe sets: 10465314 (MoGene1.0st)   1417228_at (Mouse Genome 430 2.0 Array)   1417229_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025891
Ensembl peptide - ENSMUSP00000127498
NCBI entrez gene - 12333     See in Manteia.
MGI - MGI:88263
RefSeq - NM_007600
RefSeq - NM_001110504
RefSeq Peptide - NP_001103974
RefSeq Peptide - NP_031626
swissprot - O35350
swissprot - Q3TI07
Ensembl - ENSMUSG00000024942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPN1ENSDARG00000055338Danio rerio
 zgc:55262ENSDARG00000045199Danio rerio
 CAPN1ENSG00000014216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Capn2 / O08529 / Calpain-2 catalytic subunit / P17655* / calpain 2*ENSMUSG0000002650960
Capn8 / Q91VA3 / Calpain-8 / A6NHC0*ENSMUSG0000003859956
Capn3 / Q64691 / Calpain-3 / P20807*ENSMUSG0000007911052
Capn9 / Q9D805 / Calpain-9 / O14815*ENSMUSG0000003198152
Capn11 / Q6J756 / Calpain-11 / Q9UMQ6*ENSMUSG0000005862651
Capn12 / calpain 12 / Q6ZSI9*ENSMUSG0000005408343
Capn13 / Q3UW68 / Calpain-13 / Q6MZZ7*ENSMUSG0000004370532
Capn5 / O08688 / Calpain-5 / O15484*ENSMUSG0000003554731
Capn6 / O35646 / Calpain-6 / Q9Y6Q1*ENSMUSG0000006727628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR029643  Calpain-1
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0032801 receptor catabolic process IDA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0060056 mammary gland involution IMP
 biological_processGO:0097264 self proteolysis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

Allelic Composition: Capn1tm1.1Arte/Capn1tm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm2.1Tcs,Meox2tm1(cre)Sor/Meox2+
Genetic Background: B6.129-Capn2tm1Tcs/Capn2tm2.1Tcs Meox2tm1(cre)Sor Capn1tm1Ahc

Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001794 Capns1 / calpain small subunit 1 / P04632*  / complex
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / reaction
 ENSMUSG00000078144 Capns2 / Q9D7J7 / Calpain small subunit 2 / Q96L46*  / complex






 

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