ENSMUSG00000035547


Mus musculus

Features
Gene ID: ENSMUSG00000035547
  
Biological name :Capn5
  
Synonyms : Calpain-5 / Capn5 / O08688
  
Possible biological names infered from orthology : O15484
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E1
Gene start: 98121559
Gene end: 98178274
  
Corresponding Affymetrix probe sets: 10565689 (MoGene1.0st)   10565705 (MoGene1.0st)   1418671_at (Mouse Genome 430 2.0 Array)   1422199_at (Mouse Genome 430 2.0 Array)   1422200_at (Mouse Genome 430 2.0 Array)   1449165_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116697
Ensembl peptide - ENSMUSP00000121200
Ensembl peptide - ENSMUSP00000048183
Ensembl peptide - ENSMUSP00000102729
NCBI entrez gene - 12337     See in Manteia.
MGI - MGI:1100859
RefSeq - NM_007602
RefSeq - XM_006507275
RefSeq - NM_001301250
RefSeq Peptide - NP_001288179
RefSeq Peptide - NP_031628
swissprot - D3YU84
swissprot - O08688
swissprot - Q3TPL4
swissprot - D3Z432
Ensembl - ENSMUSG00000035547
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn5aENSDARG00000103317Danio rerio
 capn5bENSDARG00000069748Danio rerio
 CAPN5ENSGALG00000040478Gallus gallus
 CAPN5ENSG00000149260Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Capn6 / O35646 / Calpain-6 / Q9Y6Q1*ENSMUSG0000006727646
Capn3 / Q64691 / Calpain-3 / P20807*ENSMUSG0000007911036
Capn1 / O35350 / Calpain-1 catalytic subunit / P07384* / calpain 1*ENSMUSG0000002494235
Capn8 / Q91VA3 / Calpain-8 / A6NHC0*ENSMUSG0000003859934
Capn2 / O08529 / Calpain-2 catalytic subunit / P17655* / calpain 2*ENSMUSG0000002650933
Capn11 / Q6J756 / Calpain-11 / Q9UMQ6*ENSMUSG0000005862633
Capn9 / Q9D805 / Calpain-9 / O14815*ENSMUSG0000003198133
Capn12 / calpain 12 / Q6ZSI9*ENSMUSG0000005408331
Capn13 / Q3UW68 / Calpain-13 / Q6MZZ7*ENSMUSG0000004370526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR033883  Calpain subdomain III
 IPR033884  Calpain C2 domain
 IPR035892  C2 domain superfamily
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0009986 cell surface ISS
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Cap2tm1a(EUCOMM)Wtsi/Cap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cap2tm1a(EUCOMM)Wtsi/Ieg

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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