ENSG00000162909


Homo sapiens

Features
Gene ID: ENSG00000162909
  
Biological name :CAPN2
  
Synonyms : calpain 2 / CAPN2 / P17655
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q41
Gene start: 223701593
Gene end: 223776018
  
Corresponding Affymetrix probe sets: 208683_at (Human Genome U133 Plus 2.0 Array)   214888_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399949
Ensembl peptide - ENSP00000413158
Ensembl peptide - ENSP00000295006
NCBI entrez gene - 824     See in Manteia.
OMIM - 114230
RefSeq - NM_001146068
RefSeq - NM_001748
RefSeq Peptide - NP_001139540
RefSeq Peptide - NP_001739
swissprot - C9JWY7
swissprot - P17655
Ensembl - ENSG00000162909
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn2aENSDARG00000091699Danio rerio
 capn2bENSDARG00000055592Danio rerio
 zgc:92480ENSDARG00000034211Danio rerio
 CAPN2ENSGALG00000009360Gallus gallus
 Capn2ENSMUSG00000026509Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPN1 / P07384 / calpain 1ENSG0000001421663
CAPN8 / A6NHC0 / calpain 8ENSG0000020369762
CAPN11 / Q9UMQ6 / calpain 11ENSG0000013722553
CAPN9 / O14815 / calpain 9ENSG0000013577350
CAPN3 / P20807 / calpain 3ENSG0000009252950
CAPN12 / Q6ZSI9 / calpain 12ENSG0000018247242
A8MX76 / CAPN14 / calpain 14ENSG0000021471136
CAPN5 / O15484 / calpain 5ENSG0000014926030
CAPN13 / Q6MZZ7 / calpain 13ENSG0000016294930
CAPN6 / Q9Y6Q1 / calpain 6ENSG0000007727427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR029539  Calpain-2
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0006508 proteolysis ISS
 biological_processGO:0007520 myoblast fusion IEA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0071230 cellular response to amino acid stimulus ISS
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030864 cortical actin cytoskeleton TAS
 cellular_componentGO:0031143 pseudopodium IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097038 perinuclear endoplasmic reticulum IDA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding NAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126247 CAPNS1 / P04632 / calpain small subunit 1  / complex
 ENSG00000153113 CAST / P20810 / calpastatin  / reaction / complex
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / reaction
 ENSG00000256812 CAPNS2 / Q96L46 / calpain small subunit 2  / complex






 

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