ENSG00000182472


Homo sapiens

Features
Gene ID: ENSG00000182472
  
Biological name :CAPN12
  
Synonyms : calpain 12 / CAPN12 / Q6ZSI9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 38730187
Gene end: 38769904
  
Corresponding Affymetrix probe sets: 228705_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473156
Ensembl peptide - ENSP00000471007
Ensembl peptide - ENSP00000471510
Ensembl peptide - ENSP00000331636
Ensembl peptide - ENSP00000469217
Ensembl peptide - ENSP00000470233
Ensembl peptide - ENSP00000470760
NCBI entrez gene - 147968     See in Manteia.
OMIM - 608839
RefSeq - XM_017026364
RefSeq - XM_017026356
RefSeq - XM_017026357
RefSeq - XM_017026358
RefSeq - XM_017026359
RefSeq - XM_017026360
RefSeq - XM_017026361
RefSeq - XM_017026362
RefSeq - XM_017026363
RefSeq - NM_144691
RefSeq - XM_017026355
RefSeq Peptide - NP_653292
swissprot - M0QZT6
swissprot - M0R052
swissprot - M0R0X4
swissprot - M0R3D7
swissprot - M0QXJ6
swissprot - M0QZ20
swissprot - Q6ZSI9
Ensembl - ENSG00000182472
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn12ENSDARG00000010758Danio rerio
 Capn12ENSMUSG00000054083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPN1 / P07384 / calpain 1ENSG0000001421643
CAPN2 / P17655 / calpain 2ENSG0000016290941
CAPN8 / A6NHC0 / calpain 8ENSG0000020369741
CAPN11 / Q9UMQ6 / calpain 11ENSG0000013722539
CAPN3 / P20807 / calpain 3ENSG0000009252938
CAPN9 / O14815 / calpain 9ENSG0000013577337
A8MX76 / CAPN14 / calpain 14ENSG0000021471133
CAPN13 / Q6MZZ7 / calpain 13ENSG0000016294929
CAPN5 / O15484 / calpain 5ENSG0000014926026
CAPN6 / Q9Y6Q1 / calpain 6ENSG0000007727425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR029545  Calpain-12
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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