ENSG00000214711


Homo sapiens

Features
Gene ID: ENSG00000214711
  
Biological name :CAPN14
  
Synonyms : A8MX76 / calpain 14 / CAPN14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p23.1
Gene start: 31173056
Gene end: 31233858
  
Corresponding Affymetrix probe sets: 1557321_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385247
Ensembl peptide - ENSP00000381805
NCBI entrez gene - 440854     See in Manteia.
OMIM - 610229
RefSeq - XM_011532866
RefSeq - NM_001321270
RefSeq - XM_011532863
RefSeq - XM_011532864
RefSeq - XM_011532865
RefSeq - NM_001145122
RefSeq Peptide - NP_001308199
RefSeq Peptide - NP_001138594
swissprot - F1LLU4
swissprot - A8MX76
Ensembl - ENSG00000214711
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-202f3.3ENSDARG00000052917Danio rerio
 si:ch211-202f3.4ENSDARG00000091723Danio rerio
 zgc:136872ENSDARG00000008553Danio rerio
 zgc:162184ENSDARG00000077217Danio rerio
 CAPN14ENSGALG00000009069Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPN11 / Q9UMQ6 / calpain 11ENSG0000013722540
CAPN9 / O14815 / calpain 9ENSG0000013577338
CAPN3 / P20807 / calpain 3ENSG0000009252938
CAPN8 / A6NHC0 / calpain 8ENSG0000020369738
CAPN1 / P07384 / calpain 1ENSG0000001421638
CAPN2 / P17655 / calpain 2ENSG0000016290937
CAPN12 / Q6ZSI9 / calpain 12ENSG0000018247235
CAPN13 / Q6MZZ7 / calpain 13ENSG0000016294934
CAPN5 / O15484 / calpain 5ENSG0000014926026
CAPN6 / Q9Y6Q1 / calpain 6ENSG0000007727425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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