ENSG00000137225


Homo sapiens

Features
Gene ID: ENSG00000137225
  
Biological name :CAPN11
  
Synonyms : calpain 11 / CAPN11 / Q9UMQ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 44158811
Gene end: 44184402
  
Corresponding Affymetrix probe sets: 207962_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431963
Ensembl peptide - ENSP00000432420
Ensembl peptide - ENSP00000381758
NCBI entrez gene - 11131     See in Manteia.
OMIM - 604822
RefSeq - XM_011514275
RefSeq - XM_006714984
RefSeq - XM_006714985
RefSeq - XM_006714987
RefSeq - XM_011514274
RefSeq - NM_007058
RefSeq Peptide - NP_008989
swissprot - E9PQZ4
swissprot - E9PIX3
swissprot - Q9UMQ6
Ensembl - ENSG00000137225
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 capn1aENSDARG00000052702Danio rerio
 capn1bENSDARG00000052748Danio rerio
 CAPN11ENSGALG00000010186Gallus gallus
 Capn11ENSMUSG00000058626Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAPN1 / P07384 / calpain 1ENSG0000001421652
CAPN2 / P17655 / calpain 2ENSG0000016290950
CAPN8 / A6NHC0 / calpain 8ENSG0000020369748
CAPN3 / P20807 / calpain 3ENSG0000009252948
CAPN9 / O14815 / calpain 9ENSG0000013577345
CAPN12 / Q6ZSI9 / calpain 12ENSG0000018247238
A8MX76 / CAPN14 / calpain 14ENSG0000021471137
CAPN13 / Q6MZZ7 / calpain 13ENSG0000016294931
CAPN5 / O15484 / calpain 5ENSG0000014926029
CAPN6 / Q9Y6Q1 / calpain 6ENSG0000007727427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR001300  Peptidase C2, calpain, catalytic domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022682  Peptidase C2, calpain, large subunit, domain III
 IPR022683  Peptidase C2, calpain, domain III
 IPR022684  Peptidase C2, calpain family
 IPR033883  Calpain subdomain III
 IPR036213  Calpain large subunit, domain III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004198 calcium-dependent cysteine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity TAS
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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