ENSG00000176749


Homo sapiens

Features
Gene ID: ENSG00000176749
  
Biological name :CDK5R1
  
Synonyms : CDK5R1 / cyclin dependent kinase 5 regulatory subunit 1 / Q15078
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 32486619
Gene end: 32491256
  
Corresponding Affymetrix probe sets: 204995_at (Human Genome U133 Plus 2.0 Array)   204996_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000318486
Ensembl peptide - ENSP00000463654
Ensembl peptide - ENSP00000464129
NCBI entrez gene - 8851     See in Manteia.
OMIM - 603460
RefSeq - XM_017025281
RefSeq - NM_003885
RefSeq - XM_011525438
RefSeq Peptide - NP_003876
swissprot - Q15078
swissprot - J3QRB5
Ensembl - ENSG00000176749
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk5r1aENSDARG00000037916Danio rerio
 cdk5r1bENSDARG00000045087Danio rerio
 CDK5R1ENSGALG00000041907Gallus gallus
 Cdk5r1ENSMUSG00000048895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK5R2 / Q13319 / cyclin dependent kinase 5 regulatory subunit 2ENSG0000017145055


Protein motifs (from Interpro)
Interpro ID Name
 IPR004944  Cyclin-dependent kinase 5 activator
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000226 microtubule cytoskeleton organization TAS
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0007158 neuron cell-cell adhesion IEA
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007413 axonal fasciculation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEA
 biological_processGO:0016241 regulation of macroautophagy NAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021722 superior olivary nucleus maturation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization ISS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0042501 serine phosphorylation of STAT protein IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045664 regulation of neuron differentiation NAS
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005874 microtubule ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016533 protein kinase 5 complex IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043292 contractile fiber IEA
 cellular_componentGO:0045298 tubulin complex ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016534 cyclin-dependent protein kinase 5 activator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding ISS
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0048487 beta-tubulin binding ISS
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models
Activated NTRK2 signals through CDK5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000126247 CAPNS1 / P04632 / calpain small subunit 1  / reaction
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000014216 CAPN1 / P07384 / calpain 1  / reaction
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / complex / reaction
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / complex / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / reaction / complex
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000162909 CAPN2 / P17655 / calpain 2  / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction / complex
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / reaction / complex
 ENSG00000256812 CAPNS2 / Q96L46 / calpain small subunit 2  / reaction






 

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