ENSDARG00000037916


Danio rerio

Features
Gene ID: ENSDARG00000037916
  
Biological name :cdk5r1a
  
Synonyms : cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35)
  
Possible biological names infered from orthology : CDK5R1 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / cyclin dependent kinase 5 regulatory subunit 1 / P61809 / Q15078
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 34821327
Gene end: 34822320
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000055261
NCBI entrez gene - 568402     See in Manteia.
RefSeq - NM_001128742
RefSeq Peptide - NP_001122214
swissprot - B3DH98
ZFIN ID - ZDB-GENE-080723-17
Ensembl - ENSDARG00000037916
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK5R1ENSGALG00000041907Gallus gallus
 CDK5R1ENSG00000176749Homo sapiens
 Cdk5r1ENSMUSG00000048895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...ENSDARG0000004508768
cdk5r2a / cyclin-dependent kinase 5, regulatory subunit 2a (p39) / Q13319* / O35926* / CDK5R2* / Cyclin-dependent kinase 5 activator 2 * / cyclin dependent kinase 5 regulatory subunit 2*ENSDARG0000007101154
si:dkeyp-92c9.2ENSDARG0000003610554
cdk5r2b / cyclin-dependent kinase 5, regulatory subunit 2b (p39) / Q13319* / O35926* / CDK5R2* / Cyclin-dependent kinase 5 activator 2 * / cyclin dependent kinase 5 regulatory subunit 2*ENSDARG0000007867147


Protein motifs (from Interpro)
Interpro ID Name
 IPR004944  Cyclin-dependent kinase 5 activator
 IPR013763  Cyclin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035622 intrahepatic bile duct development IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0016533 protein kinase 5 complex IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016534 cyclin-dependent protein kinase 5 activator activity IEA


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000036 liver and biliary system liver and biliary system functionality , ameliorated
liver and biliary system decreased functionality , abnormal
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 ZFA:0000123 liver liver intrahepatic bile duct development process quality , ameliorated
liver intrahepatic bile duct development decreased process quality , abnormal
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 ZFA:0005164 bile ductule bile ductule branchiness , ameliorated
bile ductule decreased branchiness , abnormal
bile ductule morphogenesis of a branching epithelium process quality , ameliorated
bile ductule morphogenesis of a branching epithelium decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / complex / reaction
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction / complex
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex






 

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