ENSDARG00000056683


Danio rerio

Features
Gene ID: ENSDARG00000056683
  
Biological name :cdk5
  
Synonyms : cdk5 / cyclin-dependent kinase 5
  
Possible biological names infered from orthology : Cyclin-dependent-like kinase 5 / P49615 / Q00535
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 33767771
Gene end: 33780387
  
Corresponding Affymetrix probe sets: Dr.10688.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000073666
NCBI entrez gene - 65234     See in Manteia.
swissprot - Q9DE44
ZFIN ID - ZDB-GENE-010131-2
Ensembl - ENSDARG00000056683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK5ENSG00000164885Homo sapiens
 Cdk5ENSMUSG00000028969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*ENSDARG0000002657759
cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*ENSDARG0000008755457
cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*ENSDARG0000007022847
cdk10 / cyclin-dependent kinase 10 / Q15131* / Q3UMM4*ENSDARG0000003425646
cdk4 / cyclin-dependent kinase 4 / P11802*ENSDARG0000008793744
cdk11b / cyclin-dependent kinase 11B / CDK11A* / Q9UQ88* / cyclin dependent kinase 11A*ENSDARG0000010254644
cdk21 / cyclin-dependent kinase 21ENSDARG0000003016342


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0021634 optic nerve formation IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048489 synaptic vesicle transport IBA
 biological_processGO:0048935 peripheral nervous system neuron development IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0035173 histone kinase activity IMP


Pathways (from Reactome)
Pathway description
DARPP-32 events
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain motor neuron increased amount , abnormal
Show

 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer morphology , abnormal
Show

 ZFA:0000075 spinal cord spinal cord motor neuron increased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer morphology , abnormal
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 ZFA:0000152 retina retina morphology , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II aplastic , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer morphology , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer morphology , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron displaced to spinal cord axis, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / complex / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction / complex
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex






 

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