ENSDARG00000017803


Danio rerio

Features
Gene ID: ENSDARG00000017803
  
Biological name :gsk3b
  
Synonyms : glycogen synthase kinase 3 beta / gsk3b
  
Possible biological names infered from orthology : P49841 / Q9WV60
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 9577743
Gene end: 9671244
  
Corresponding Affymetrix probe sets: Dr.4934.1.A1_at (Zebrafish Array)   Dr.8166.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000027785
NCBI entrez gene - 30654     See in Manteia.
RefSeq - XM_009304494
RefSeq Peptide - NP_571456
swissprot - Q9YH60
ZFIN ID - ZDB-GENE-990714-4
Ensembl - ENSDARG00000017803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GSK3BENSGALG00000014977Gallus gallus
 GSK3BENSG00000082701Homo sapiens
 Gsk3bENSMUSG00000022812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*ENSDARG0000005246890
gsk3ab / glycogen synthase kinase 3 alpha b / GSK3A* / Q2NL51* / P49840* / AC006486.1* / glycogen synthase kinase 3 alpha*ENSDARG0000001568177
gsk3aa / glycogen synthase kinase 3 alpha a / GSK3A* / Q2NL51* / P49840* / AC006486.1* / glycogen synthase kinase 3 alpha*ENSDARG0000002950176


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033573  Glycogen synthase kinase-3 beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart linear , abnormal
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 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature angiogenesis process quality , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic , abnormal
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 ZFA:0005065 heart valve heart valve aplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / reaction
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / reaction
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / reaction
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / reaction
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction
 ENSDARG00000010515 dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / reaction / complex
 ENSDARG00000055554 wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*  / complex / reaction
 ENSDARG00000055552 dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / reaction / complex
 ENSDARG00000102964 axin1 / O15169*  / complex
 ENSDARG00000106062 fzd1 / frizzled class receptor 1 / Q9UP38*  / complex / reaction






 

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