ENSDARG00000102964


Danio rerio

Features
Gene ID: ENSDARG00000102964
  
Biological name :axin1
  
Synonyms : axin1
  
Possible biological names infered from orthology : O15169
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 43578975
Gene end: 43662495
  
Corresponding Affymetrix probe sets: Dr.17733.1.S1_at (Zebrafish Array)   Dr.8294.1.S1_at (Zebrafish Array)   NM_131503_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135253
Ensembl peptide - ENSDARP00000145013
Ensembl peptide - ENSDARP00000135613
NCBI entrez gene - 57931     See in Manteia.
RefSeq - NM_131503
RefSeq Peptide - NP_571578
swissprot - A0A0R4IKU7
swissprot - A0A0R4II61
ZFIN ID - ZDB-GENE-000403-1
Ensembl - ENSDARG00000102964
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AXIN1ENSGALG00000029402Gallus gallus
 AXIN1ENSG00000103126Homo sapiens
 Axin1ENSMUSG00000024182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
axin2 / P57095 / axin 2 (conductin, axil) / O88566* / Q9Y2T1*ENSDARG0000010014941


Protein motifs (from Interpro)
Interpro ID Name
 IPR001158  DIX domain
 IPR014936  Axin beta-catenin binding
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR029071  Ubiquitin-like domain superfamily
 IPR029797  Axin-1
 IPR032101  Axin-1/2, tankyrase-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000019 epiphysis epiphysis increased size , abnormal
epiphysis photoreceptor cell increased amount , abnormal
epiphysis neuron increased amount , abnormal
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 ZFA:0000022 floor plate floor plate quality , abnormal
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 ZFA:0000047 peripheral olfactory organ peripheral olfactory organ absent , abnormal
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 ZFA:0000048 olfactory placode olfactory placode aplastic , abnormal
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 ZFA:0000050 optic vesicle optic vesicle absent , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000059 postoptic commissure postoptic commissure aplastic , abnormal
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 ZFA:0000060 prechordal plate prechordal plate antero-lateral region decreased size , abnormal
Show

 ZFA:0000079 telencephalon telencephalon decreased size , abnormal
telencephalon aplastic , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
eye absent , abnormal
eye aplastic , abnormal
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 ZFA:0000109 forebrain forebrain quality , abnormal
forebrain decreased size , abnormal
forebrain absent , abnormal
Show

 ZFA:0000114 heart heart linear , abnormal
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 ZFA:0000162 trigeminal placode trigeminal placode increased size , abnormal
trigeminal placode sensory neuron mislocalised anteriorly , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000509 epithalamus epithalamus right side mislocalised , abnormal
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 ZFA:0000571 presumptive telencephalon presumptive telencephalon aplastic , abnormal
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 ZFA:0000574 presumptive diencephalon presumptive diencephalon increased size , abnormal
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 ZFA:0000653 dorsal thalamus dorsal thalamus cellular quality , abnormal
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 ZFA:0000706 posterior intestine posterior intestine epithelial cell increased amount , abnormal
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 ZFA:0001076 intestinal bulb intestinal bulb epithelial cell increased amount , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001108 anterior commissure anterior commissure aplastic , abnormal
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 ZFA:0001282 adenohypophysis adenohypophysis decreased size , abnormal
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 ZFA:0001317 endocardial cushion endocardial cushion hyperplastic , abnormal
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 ZFA:0001318 cardiac jelly cardiac jelly increased volume , abnormal
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 ZFA:0001338 intestine intestine morphology , abnormal
intestine increased thickness , abnormal
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 ZFA:0001360 parapineal organ parapineal organ position , abnormal
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 ZFA:0001366 tract of the postoptic commissure tract of the postoptic commissure primary neuron morphology , abnormal
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 ZFA:0005124 intestinal epithelium intestinal epithelium hypertrophic , abnormal
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 ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium cellular quality , abnormal
intestinal bulb epithelium increased thickness , abnormal
intestinal bulb epithelium disorganized , abnormal
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 ZFA:0005757 mid diencephalic organizer mid diencephalic organizer increased thickness , abnormal
mid diencephalic organizer cellular quality , abnormal
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 ZFA:0005852 replacement tooth 4V replacement tooth 4V immature , abnormal
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 ZFA:0007001 dorso-rostral cluster dorso-rostral cluster absent , abnormal
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 ZFA:0009399 intestinal epithelial cell intestinal epithelial cell proliferative , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010515 dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / complex / reaction
 ENSDARG00000055554 wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*  / complex / reaction
 ENSDARG00000038067 A9JRZ0 / smurf2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSDARG00000062897 tnksb / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b / TNKS* / Q6PFX9* / O95271* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*  / complex / reaction
 ENSDARG00000077650 tnksa / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase a / TNKS* / Q6PFX9* / O95271* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*  / reaction / complex
 ENSDARG00000055552 dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*  / reaction / complex
 ENSDARG00000089981 rnf146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / complex / reaction
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / complex
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / complex
 ENSDARG00000106062 fzd1 / frizzled class receptor 1 / Q9UP38*  / reaction / complex






 

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