ENSDARG00000062897


Danio rerio

Features
Gene ID: ENSDARG00000062897
  
Biological name :tnksb
  
Synonyms : tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b / tnksb
  
Possible biological names infered from orthology : O95271 / Q6PFX9 / tankyrase / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / TNKS
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 8964926
Gene end: 9027936
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000085830
Ensembl peptide - ENSDARP00000141080
NCBI entrez gene - 567533     See in Manteia.
RefSeq - NM_001089415
RefSeq - XM_005171745
RefSeq Peptide - NP_001082884
swissprot - A3KGU1
swissprot - A0A0R4IYN3
ZFIN ID - ZDB-GENE-030131-4865
Ensembl - ENSDARG00000062897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNKSENSGALG00000043164Gallus gallus
 TNKSENSG00000173273Homo sapiens
 TnksENSMUSG00000031529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnksa / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase a / TNKS* / Q6PFX9* / O95271* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*ENSDARG0000007765088
ank3a / ank3b / ankyrin 3b / ANK3* / G5E8K5* / Q12955* / ankyrin 3*ENSDARG0000006173619
ank2a / ankyrin 2a, neuronal / ANK2* / Q01484* / ankyrin 2*ENSDARG0000000902618
ank1a / si:ch211-173b16.3 / ankyrin 1, erythrocytic a / ANK1* / P16157* / Q02357* / ankyrin 1*ENSDARG0000005909316
ank1b / ankyrin 1, erythrocytic b / ANK1* / P16157* / Q02357* / ankyrin 1*ENSDARG0000007477715
ankrd52a / ankyrin repeat domain 52a / Q8BTI7* / Q8NB46* / ANKRD52* / ankyrin repeat domain 52* / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C *ENSDARG0000003682613
ankrd44 / ankyrin repeat domain 44 / B2RXR6* / Q8N8A2* / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B *ENSDARG0000002602813
ankrd28b / ankyrin repeat domain 28b / O15084* / Q505D1* / ANKRD28* / ankyrin repeat domain 28* / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A *ENSDARG0000000902312
si:dkey-86e18.2ENSDARG000000927588
invs / inversin / Q9Y283* / inversin isoform 2 *ENSDARG000000022138
ank3b / ankyrin 3b / ANK3* / G5E8K5* / Q12955* / ankyrin 3*ENSDARG000000775826
CABZ01073736.1 / E5RJM6* / ANKRD65* / ankyrin repeat domain 65*ENSDARG000000994386
CABZ01071939.1 / O15084* / ANKRD28* / ankyrin repeat domain 28*ENSDARG000000863265
si:ch211-203b8.6ENSDARG000000682744
ank2b / ankyrin 2b, neuronal / ANK2* / Q01484* / Q8C8R3* / ankyrin 2*ENSDARG000000433133


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR028731  Tankyrase-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0051225 spindle assembly IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001197 pars intermedia pars intermedia melanocyte stimulating hormone secreting cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000089981 rnf146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / complex / reaction
 ENSDARG00000102964 axin1 / O15169*  / reaction / complex
 ENSDARG00000100149 axin2 / P57095 / axin 2 (conductin, axil) / O88566* / Q9Y2T1*  / reaction / complex






 

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