ENSG00000173273


Homo sapiens

Features
Gene ID: ENSG00000173273
  
Biological name :TNKS
  
Synonyms : O95271 / tankyrase / TNKS
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p23.1
Gene start: 9555914
Gene end: 9782346
  
Corresponding Affymetrix probe sets: 1569391_at (Human Genome U133 Plus 2.0 Array)   202561_at (Human Genome U133 Plus 2.0 Array)   216695_s_at (Human Genome U133 Plus 2.0 Array)   217121_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430920
Ensembl peptide - ENSP00000311579
Ensembl peptide - ENSP00000431098
Ensembl peptide - ENSP00000428185
Ensembl peptide - ENSP00000429890
Ensembl peptide - ENSP00000428299
NCBI entrez gene - 8658     See in Manteia.
OMIM - 603303
RefSeq - NM_003747
RefSeq - XM_011543847
RefSeq - XM_011543846
RefSeq - XM_011543845
RefSeq - XM_006716263
RefSeq Peptide - NP_003738
swissprot - E7EWY6
swissprot - O95271
swissprot - H0YAW5
swissprot - A0A0C4DGE3
swissprot - E5RHD2
swissprot - E7EQ52
Ensembl - ENSG00000173273
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnksaENSDARG00000077650Danio rerio
 tnksbENSDARG00000062897Danio rerio
 TNKSENSGALG00000043164Gallus gallus
 TnksENSMUSG00000031529Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNKS2 / Q9H2K2 / tankyrase 2ENSG0000010785472
ANK2 / Q01484 / ankyrin 2ENSG0000014536227
ANK3 / Q12955 / ankyrin 3ENSG0000015115026
ANK1 / P16157 / ankyrin 1ENSG0000002953423
Q8NB46 / ANKRD52 / ankyrin repeat domain 52ENSG0000013964518
O15084 / ANKRD28 / ankyrin repeat domain 28ENSG0000020656018
Q8N8A2 / ANKRD44 / ankyrin repeat domain 44ENSG0000006541317
INVS / Q9Y283 / inversinENSG0000011950913
E5RJM6 / ANKRD65 / ankyrin repeat domain 65ENSG000002350988


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR028731  Tankyrase-1
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006471 protein ADP-ribosylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0032210 regulation of telomere maintenance via telomerase IC
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051225 spindle assembly IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051973 positive regulation of telomerase activity IDA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IMP
 biological_processGO:0070212 protein poly-ADP-ribosylation IMP
 biological_processGO:0070213 protein auto-ADP-ribosylation IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway TAS
 biological_processGO:1904355 positive regulation of telomere capping IMP
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IMP
 biological_processGO:1904743 negative regulation of telomeric DNA binding IMP
 biological_processGO:1904908 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000242 pericentriolar material TAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
XAV939 inhibits tankyrase, stabilizing AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103126 AXIN1 / O15169  / reaction / complex
 ENSG00000168646 AXIN2 / Q9Y2T1  / complex / reaction
 ENSG00000118518 Q9NTX7 / RNF146 / ring finger protein 146  / complex / reaction
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / reaction
 ENSG00000115464 USP34 / Q70CQ2 / ubiquitin specific peptidase 34  / reaction






 

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