ENSG00000107854


Homo sapiens

Features
Gene ID: ENSG00000107854
  
Biological name :TNKS2
  
Synonyms : Q9H2K2 / tankyrase 2 / TNKS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q23.32
Gene start: 91798312
Gene end: 91865276
  
Corresponding Affymetrix probe sets: 218228_s_at (Human Genome U133 Plus 2.0 Array)   222562_s_at (Human Genome U133 Plus 2.0 Array)   222563_s_at (Human Genome U133 Plus 2.0 Array)   241909_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360689
NCBI entrez gene - 80351     See in Manteia.
OMIM - 607128
RefSeq - XM_017016700
RefSeq - NM_025235
RefSeq - XM_017016698
RefSeq - XM_017016699
RefSeq - XM_005270185
RefSeq - XM_011540213
RefSeq - XM_011540215
RefSeq - XM_017016696
RefSeq - XM_017016697
RefSeq Peptide - NP_079511
swissprot - Q9H2K2
Ensembl - ENSG00000107854
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNKS2ENSGALG00000014614Gallus gallus
 Tnks2ENSMUSG00000024811Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNKS / O95271 / tankyraseENSG0000017327382
ANK2 / Q01484 / ankyrin 2ENSG0000014536230
ANK3 / Q12955 / ankyrin 3ENSG0000015115029
ANK1 / P16157 / ankyrin 1ENSG0000002953425
Q8NB46 / ANKRD52 / ankyrin repeat domain 52ENSG0000013964521
O15084 / ANKRD28 / ankyrin repeat domain 28ENSG0000020656020
Q8N8A2 / ANKRD44 / ankyrin repeat domain 44ENSG0000006541319
INVS / Q9Y283 / inversinENSG0000011950914
E5RJM6 / ANKRD65 / ankyrin repeat domain 65ENSG000002350989


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006471 protein ADP-ribosylation IDA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IC
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0070198 protein localization to chromosome, telomeric region IMP
 biological_processGO:0070213 protein auto-ADP-ribosylation IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway TAS
 biological_processGO:1904355 positive regulation of telomere capping IMP
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000242 pericentriolar material IDA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IC
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
XAV939 inhibits tankyrase, stabilizing AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103126 AXIN1 / O15169  / reaction / complex
 ENSG00000118518 Q9NTX7 / RNF146 / ring finger protein 146  / complex / reaction
 ENSG00000168646 AXIN2 / Q9Y2T1  / reaction / complex
 ENSG00000171862 PTEN / P60484 / phosphatase and tensin homolog  / reaction
 ENSG00000115464 USP34 / Q70CQ2 / ubiquitin specific peptidase 34  / reaction






 

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