ENSMUSG00000024811


Mus musculus

Features
Gene ID: ENSMUSG00000024811
  
Biological name :Tnks2
  
Synonyms : Q3UES3 / Tankyrase-2 / Tnks2
  
Possible biological names infered from orthology : Q9H2K2
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 36834232
Gene end: 36893477
  
Corresponding Affymetrix probe sets: 10462724 (MoGene1.0st)   1428388_at (Mouse Genome 430 2.0 Array)   1447522_s_at (Mouse Genome 430 2.0 Array)   1452772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025729
Ensembl peptide - ENSMUSP00000126888
Ensembl peptide - ENSMUSP00000132440
Ensembl peptide - ENSMUSP00000133253
NCBI entrez gene - 74493     See in Manteia.
MGI - MGI:1921743
RefSeq - XM_011247382
RefSeq - NM_001163635
RefSeq - XM_006527408
RefSeq - XM_006527409
RefSeq Peptide - NP_001157107
swissprot - Q3UES3
swissprot - F6YVU7
swissprot - F6V619
swissprot - F6S169
Ensembl - ENSMUSG00000024811
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNKS2ENSGALG00000014614Gallus gallus
 TNKS2ENSG00000107854Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*ENSMUSG0000003152981
Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*ENSMUSG0000003282628
Ank3 / G5E8K5 / Ankyrin-3 / Q12955*ENSMUSG0000006960126
Ank1 / Q02357 / Ankyrin-1 / P16157*ENSMUSG0000003154325
Q8BTI7 / Ankrd52 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8NB46* / ankyrin repeat domain 52*ENSMUSG0000001449821
Q505D1 / Ankrd28 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A / O15084* / ankyrin repeat domain 28*ENSMUSG0000001449620
B2RXR6 / Ankrd44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / Q8N8A2* / ankyrin repeat domain 44*ENSMUSG0000005233120
Invs / inversin isoform 2 / Q9Y283* / inversin*ENSMUSG0000002834413
Ankrd65 / ankyrin repeat domain 65 / E5RJM6*ENSMUSG000000784879


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002110  Ankyrin repeat
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000723 telomere maintenance ISS
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0070198 protein localization to chromosome, telomeric region IEA
 biological_processGO:0070213 protein auto-ADP-ribosylation IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
Degradation of AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Tnks2tm1Susm/Tnks2tm1Susm
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnks2tm1.1Susm/Tnks2tm1.1Susm
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001711 abnormal placenta 
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tnks2tm1Susm/Tnks2tm1Susm
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnks2tm1.1Susm/Tnks2tm1.1Susm
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tnks2tm1.1Susm/Tnks2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Tnkstm1.1Yjc/Tnks+,Tnks2tm1.1Yjc/Tnks2tm1.1Yjc
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0012134 absent umbilical cord "absence of or failure to form the connective stalk between the fetus and the placenta" [MGI:anna]
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Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0012301 absent umbilical cord blood vessels "absence of any of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton s jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place" [MGI:anna]
Show

Allelic Composition: Stat1tm1Tdec/Stat1tm1Tdec
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024182 Axin1 / O15169*  / complex / reaction
 ENSMUSG00000000142 Axin2 / O88566 / Q9Y2T1*  / complex / reaction
 ENSMUSG00000013663 Pten / O08586 / phosphatase and tensin homolog / P60484*  / reaction
 ENSMUSG00000038876 Q9CZW6 / Rnf146 / ring finger protein 146 / Q9NTX7*  / complex / reaction
 ENSMUSG00000056342 Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*  / reaction






 

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