| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000531 | right pulmonary isomerism | "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530] |
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Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0000542 | left-sided isomerism | "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the left atrium" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Invsinv/Invs+
Genetic Background: FVB/N-Invsinv
|
| MP:0000611 | jaundice | "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0000644 | dextrocardia | "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001944 | abnormal pancreas morphology | "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0002766 | situs inversus | "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0002767 | situs ambiguus | "abnormal organ position" [J:62608] |
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Allelic Composition: Foxc1tm1Blh/Foxc1+,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss
|
| MP:0003178 | left pulmonary isomerism | "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051] |
Show
Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0003197 | kidney calcification | "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0003606 | kidney failure | "cessation of renal function" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0003917 | increased kidney weight | "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004066 | abnormal Henson s node morphology | "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004110 | transposition of great arteries | "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0004159 | double aortic arch | "defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0004190 | abnormal direction of embryo turning | "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004194 | abnormal kidney pelvis morphology | "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004252 | abnormal direction of looping morphogenesis | "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0004860 | dilated kidney collecting duct | "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005083 | abnormal biliary tract morphology | "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005491 | islet cell hyperplasia | "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0006062 | abnormal vena cava morphology | "structural malformation of either of the two largest veins in the body " [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0006117 | aortic valve stenosis | "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0008461 | left atrial isomerism | "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0008933 | abnormal embryonic cilium physiology | "any functional anomaly of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0009050 | dilated proximal convoluted tubules | "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0009144 | dilated pancreatic duct | "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667] |
Show
Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0009145 | abnormal pancreatic acinus morphology | "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0009146 | abnormal pancreatic acinar cell morphology | "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0009149 | decreased pancreatic acinar cell number | "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0009254 | disorganized pancreatic islets | "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0010431 | atrial situs inversus | "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0010541 | aorta hypoplasia | "underdevelopment or reduced size of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0010808 | right-sided stomach | "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0010854 | lung situs inversus | "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
Allelic Composition: Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N
|
| MP:0011250 | abdominal situs ambiguus | "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396] |
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Allelic Composition: Invsinv/Invsinv
Genetic Background: FVB/N-Invsinv
|
| MP:0011307 | kidney medulla cysts | "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011308 | kidney corticomedullary cysts | "development of abnormal membranous sacs in the corticomedullary junction of the kidney" [MGI:anna] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011341 | abnormal loop of Henle descending limb morphology | "any structural anomaly of the portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure" [MGI:anna] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011344 | abnormal loop of Henle ascending limb thick segment morphology | "any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [MGI:anna] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011352 | proximal convoluted tubule brush border loss | "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011425 | abnormal kidney interstitium morphology | "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011501 | increased glomerular capsule space | "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011682 | renal glomerulus cysts | "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0012027 | abnormal embryonic cilium location or orientation | "embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern" [MGI:csmith] |
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Allelic Composition: Itgb1bp2tm1Tron/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
