ENSMUSG00000032826


Mus musculus

Features
Gene ID: ENSMUSG00000032826
  
Biological name :Ank2
  
Synonyms : Ank2 / Ankyrin-2 / Q8C8R3
  
Possible biological names infered from orthology : Q01484
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G2
Gene start: 126921612
Gene end: 127499350
  
Corresponding Affymetrix probe sets: 10501971 (MoGene1.0st)   1434264_at (Mouse Genome 430 2.0 Array)   1434265_s_at (Mouse Genome 430 2.0 Array)   1440042_at (Mouse Genome 430 2.0 Array)   1440043_at (Mouse Genome 430 2.0 Array)   1444023_at (Mouse Genome 430 2.0 Array)   1459317_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140700
Ensembl peptide - ENSMUSP00000138781
Ensembl peptide - ENSMUSP00000148296
Ensembl peptide - ENSMUSP00000043765
Ensembl peptide - ENSMUSP00000138089
Ensembl peptide - ENSMUSP00000138157
Ensembl peptide - ENSMUSP00000138231
Ensembl peptide - ENSMUSP00000138251
Ensembl peptide - ENSMUSP00000138279
Ensembl peptide - ENSMUSP00000138323
Ensembl peptide - ENSMUSP00000138373
Ensembl peptide - ENSMUSP00000138487
Ensembl peptide - ENSMUSP00000138602
Ensembl peptide - ENSMUSP00000138620
Ensembl peptide - ENSMUSP00000138730
Ensembl peptide - ENSMUSP00000138747
Ensembl peptide - ENSMUSP00000138753
NCBI entrez gene - 109676     See in Manteia.
MGI - MGI:88025
RefSeq - XM_017319438
RefSeq - XM_011239992
RefSeq - XM_011239993
RefSeq - XM_011239994
RefSeq - XM_011239995
RefSeq - XM_011239996
RefSeq - XM_017319425
RefSeq - XM_017319426
RefSeq - XM_017319427
RefSeq - XM_017319428
RefSeq - XM_017319429
RefSeq - XM_017319430
RefSeq - XM_017319431
RefSeq - XM_017319432
RefSeq - XM_017319433
RefSeq - XM_017319434
RefSeq - XM_017319435
RefSeq - XM_017319436
RefSeq - XM_017319437
RefSeq - NM_001327938
RefSeq - NM_001327939
RefSeq - NM_178655
RefSeq - XM_006500880
RefSeq - XM_006500881
RefSeq - XM_006500884
RefSeq - XM_006500885
RefSeq - XM_006500886
RefSeq - XM_006500887
RefSeq - XM_006500888
RefSeq - XM_006500889
RefSeq - XM_006500890
RefSeq - XM_006500891
RefSeq - XM_006500893
RefSeq - XM_006500894
RefSeq - XM_006500895
RefSeq - XM_006500898
RefSeq - XM_006500899
RefSeq - XM_006500900
RefSeq - XM_006500901
RefSeq - XM_006500902
RefSeq - XM_006500903
RefSeq - XM_006500904
RefSeq - XM_006500906
RefSeq - XM_011239986
RefSeq - XM_011239987
RefSeq - XM_011239988
RefSeq - XM_011239989
RefSeq - XM_011239990
RefSeq - XM_011239991
RefSeq Peptide - NP_848770
RefSeq Peptide - NP_001314867
RefSeq Peptide - NP_001314868
swissprot - A0A087WRM9
swissprot - Q8C8R3
swissprot - S4R1B7
swissprot - S4R1I1
swissprot - S4R1J9
swissprot - S4R1M4
swissprot - S4R1Q5
swissprot - S4R1U2
swissprot - S4R241
swissprot - S4R2D6
swissprot - S4R2F3
swissprot - A0A1D5RLB2
swissprot - S4R2Q9
swissprot - S4R2R5
swissprot - S4R2T7
Ensembl - ENSMUSG00000032826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ank2aENSDARG00000009026Danio rerio
 ank2bENSDARG00000043313Danio rerio
 ANK2ENSGALG00000012044Gallus gallus
 ANK2ENSG00000145362Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ank3 / G5E8K5 / Ankyrin-3 / Q12955*ENSMUSG0000006960129
Ank1 / Q02357 / Ankyrin-1 / P16157*ENSMUSG0000003154325
Tnks / Q6PFX9 / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase / O95271* / tankyrase*ENSMUSG000000315299
Tnks2 / Q3UES3 / Tankyrase-2 / Q9H2K2*ENSMUSG000000248118
Q505D1 / Ankrd28 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A / O15084* / ankyrin repeat domain 28*ENSMUSG000000144967
Q8BTI7 / Ankrd52 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C / Q8NB46* / ankyrin repeat domain 52*ENSMUSG000000144987
B2RXR6 / Ankrd44 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B / Q8N8A2* / ankyrin repeat domain 44*ENSMUSG000000523317
Invs / inversin isoform 2 / Q9Y283* / inversin*ENSMUSG000000283446
Ankrd65 / ankyrin repeat domain 65 / E5RJM6*ENSMUSG000000784873


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000906  ZU5 domain
 IPR002110  Ankyrin repeat
 IPR011029  Death-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0003283 atrial septum development IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030913 paranodal junction assembly IEA
 biological_processGO:0031647 regulation of protein stability IC
 biological_processGO:0033292 T-tubule organization IMP
 biological_processGO:0033365 protein localization to organelle IEA
 biological_processGO:0034394 protein localization to cell surface IMP
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0036309 protein localization to M-band IMP
 biological_processGO:0036371 protein localization to T-tubule IMP
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0043268 positive regulation of potassium ion transport IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051597 response to methylmercury IEA
 biological_processGO:0051924 regulation of calcium ion transport IMP
 biological_processGO:0051928 positive regulation of calcium ion transport IMP
 biological_processGO:0055117 regulation of cardiac muscle contraction IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IEA
 biological_processGO:0070972 protein localization to endoplasmic reticulum IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IMP
 biological_processGO:0086005 ventricular cardiac muscle cell action potential IEA
 biological_processGO:0086014 atrial cardiac muscle cell action potential IMP
 biological_processGO:0086015 SA node cell action potential IMP
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential IMP
 biological_processGO:0086066 atrial cardiac muscle cell to AV node cell communication IMP
 biological_processGO:0086070 SA node cell to atrial cardiac muscle cell communication IMP
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IMP
 biological_processGO:0098904 regulation of AV node cell action potential IMP
 biological_processGO:0098907 regulation of SA node cell action potential IMP
 biological_processGO:0098910 regulation of atrial cardiac muscle cell action potential IMP
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IMP
 biological_processGO:1901019 regulation of calcium ion transmembrane transporter activity IMP
 biological_processGO:1901021 positive regulation of calcium ion transmembrane transporter activity IMP
 biological_processGO:2001257 regulation of cation channel activity IMP
 biological_processGO:2001259 positive regulation of cation channel activity IMP
 cellular_componentGO:0005622 intracellular IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0031430 M band IMP
 cellular_componentGO:0031672 A band IDA
 cellular_componentGO:0042383 sarcolemma IMP
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043034 costamere IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IMP
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030507 spectrin binding IBA
 molecular_functionGO:0030674 protein binding, bridging IMP
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Interaction between L1 and Ankyrins
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ank2tm2.1Bnt/Ank2+
Genetic Background: STOCK Ank2tm2Bnt/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ank2tm2.1Bnt/Ank2tm2.1Bnt
Genetic Background: STOCK Ank2tm2Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2+
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2+
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
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Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm2.1Bnt/Ank2+
Genetic Background: STOCK Ank2tm2Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2+
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2+
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0009682 abnormal anterior corticospinal tract morphology "any structural anomaly of the small bundle of corticospinal motor fibers that do not cross the midline at the pyramidal decussation and descend into the anterior funiculus of the spinal cord; the anterior corticospinal tract controls central axial and girdle muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0009683 abnormal lateral corticospinal tract morphology "any structural anomaly of the large bundle of corticospinal motor fibers that cross the midline at the pyramidal decussation and descend in the dorsal half of the lateral funiculus; the lateral corticospinal tract controls movement of contralateral limbs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ank2tm2.1Bnt/Ank2tm2.1Bnt
Genetic Background: STOCK Ank2tm2Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0012462 decreased brain internal capsule size "reduced size of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Ank2tm2.1Bnt/Ank2tm2.1Bnt
Genetic Background: STOCK Ank2tm2Bnt/J

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ank2tm3.1Bnt/Ank2tm3.1Bnt
Genetic Background: B6.129(C)-Ank2tm3.1Bnt/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / reaction / complex
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / reaction / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex / reaction
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction






 

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