ENSMUSG00000062825


Mus musculus

Features
Gene ID: ENSMUSG00000062825
  
Biological name :Actg1
  
Synonyms : Actg1 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63260
  
Possible biological names infered from orthology : actin gamma 1 / P63261
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120345690
Gene end: 120348542
  
Corresponding Affymetrix probe sets: 10393754 (MoGene1.0st)   10406417 (MoGene1.0st)   10506424 (MoGene1.0st)   10571653 (MoGene1.0st)   1415779_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071486
Ensembl peptide - ENSMUSP00000101821
Ensembl peptide - ENSMUSP00000087043
Ensembl peptide - ENSMUSP00000134296
Ensembl peptide - ENSMUSP00000101822
Ensembl peptide - ENSMUSP00000134070
NCBI entrez gene - 11465     See in Manteia.
MGI - MGI:87906
RefSeq - NM_009609
RefSeq - NM_001313923
RefSeq Peptide - NP_033739
RefSeq Peptide - NP_001300852
swissprot - Q4KL81
swissprot - B1ATY1
swissprot - F8WGM8
swissprot - G3UYG0
swissprot - G3UZ07
swissprot - P63260
Ensembl - ENSMUSG00000062825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actb1ENSDARG00000037746Danio rerio
 actb2ENSDARG00000037870Danio rerio
 ACTG1ENSG00000184009Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*ENSMUSG0000002958099
Acta1 / P68134 / Actin, alpha skeletal muscle / P68133* / actin, alpha 1, skeletal muscle*ENSMUSG0000003197294
Actg2 / P63268 / Actin, gamma-enteric smooth muscle / P63267* / actin, gamma 2, smooth muscle, enteric*ENSMUSG0000005943094
Acta2 / P62737 / Actin, aortic smooth muscle Actin, aortic smooth muscle, intermediate form / P62736* / actin, alpha 2, smooth muscle, aorta*ENSMUSG0000003578394
Actc1 / P68033 / Actin, alpha cardiac muscle 1 / P68032*ENSMUSG0000006861494
Actbl2 / Q8BFZ3 / Beta-actin-like protein 2 / Q562R1* / actin, beta like 2*ENSMUSG0000005519492
Actr1b / Q8R5C5 / Beta-centractin / P42025* / ARP1 actin related protein 1 homolog B*ENSMUSG0000003735155
Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*ENSMUSG0000002522854
Actrt2 / Q9D9L5 / Actin-related protein T2 / Q8TDY3*ENSMUSG0000005127650
Gm498ENSMUSG0000003108549
Actrt1 / Q9D9J3 / Actin-related protein T1 / Q8TDG2*ENSMUSG0000004661548
Actrt3 / Q8BXF8 / Actin-related protein T3 / Q9BYD9*ENSMUSG0000003773746
Actl7b / Q9QY83 / actin-like 7b / Q9Y614*ENSMUSG0000007098044
Actl7a / Q9QY84 / actin-like 7a / Q9Y615*ENSMUSG0000007097943
Actl9 / Q8CG27 / Actin-like protein 9 / Q8TC94* / actin like 9*ENSMUSG0000009251941
Actl11 / actin-like 11ENSMUSG0000006636839


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR020902  Actin/actin-like conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0045214 sarcomere organization IDA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0043034 costamere TAS
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0070062 extracellular exosome ISO
 cellular_componentGO:0097433 dense body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
Adherens junctions interactions
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
MAP2K and MAPK activation
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(Atoh1-cre)1Bfri/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actg1tm1Erv/Actg1tm1.1Erv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(Atoh1-cre)1Bfri/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actg1tm1Erv/Actg1tm1.1Erv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Tnfsf14tm1Lpc/Tnfsf14tm1Lpc
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Actg1tm1.2Erv/Actg1tm1.2Erv,Tg(Atoh1-cre)1Bfri/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction / complex
 ENSMUSG00000004951 Hspb1 / P14602 / Heat shock protein beta-1 / P04792* / heat shock protein family B (small) member 1*  / complex
 ENSMUSG00000008859 Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*  / reaction / complex
 ENSMUSG00000021262 Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / - / complex / reaction
 ENSMUSG00000022272 Myo10 / F8VQB6 / Mus musculus myosin X (Myo10), transcript variant 3, mRNA. / Q9HD67* / myosin X*  / complex / reaction
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex
 ENSMUSG00000025372 Baiap2 / Q8BKX1 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q9UQB8* / BAI1 associated protein 2*  / complex / reaction
 ENSMUSG00000031543 Ank1 / Q02357 / Ankyrin-1 / P16157*  / reaction / complex
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / reaction / complex
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / reaction / complex
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex / reaction
 ENSMUSG00000017774 Myo1c / Q9WTI7 / Unconventional myosin-Ic / O00159* / myosin IC*  / complex / reaction
 ENSMUSG00000026425 Q91Z67 / Srgap2 / SLIT-ROBO Rho GTPase-activating protein 2 / P0DJJ0* / P0DMP2* / O75044* / SRGAP2B* / SRGAP2C* / SLIT-ROBO Rho GTPase activating protein 2C* / SLIT-ROBO Rho GTPase activat...  / reaction / complex
 ENSMUSG00000006219 Fblim1 / Q71FD7 / Filamin-binding LIM protein 1 / Q8WUP2*  / complex / reaction
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / complex / reaction
 ENSMUSG00000068699 Flnc / Q8VHX6 / Filamin-C / Q14315*  / reaction / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex
 ENSMUSG00000033196 Myh2 / myosin heavy chain 2 / Q9UKX2*  / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000055805 Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*  / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000034593 Myo5a / Q99104 / Unconventional myosin-Va / Q9Y4I1* / myosin VA*  / complex
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex
 ENSMUSG00000032826 Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000028068 Iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*  / reaction / complex
 ENSMUSG00000021676 Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2 / Q13576* / IQ motif containing GTPase activating protein 2*  / reaction / complex
 ENSMUSG00000052397 Ezr / Ezrin / P26040 / P15311*  / reaction / complex
 ENSMUSG00000023008 Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / - / reaction
 ENSMUSG00000030536 Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*  / complex / reaction






 

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